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. 2024 Dec 24;15:1501009. doi: 10.3389/fimmu.2024.1501009

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Copyright © 2024 Wang, Lin, Zhang, Zhang, Sun, Yang, Zhang, Yuan, Zhang, Chen and Wen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CPVL and MSR1 in macrophages are genes significantly associated with the prognosis of TNBC patients. (A) UMAP plot of immune cells, showing further subclustering of the cell populations. (B) Bubble plot illustrating the expression patterns of marker genes in the different immune cell subpopulations. (C) Repeated analysis from the image (A), highlighting the impact of different immune cell subpopulations on prognosis. (D) Cross-validated macrophage prognostic scores from the image (C) were used to generate Kaplan-Meier curves, showing genes with opposite effects on prognosis at the 50% cutoff. (E) Display of the primary expression situation of CPVL and MSR1 in macrophages. (F) The degree of macrophage infiltration in patients’ tumors was first calculated using “CIBERSORT”, followed by the application of a univariate Cox model to assess the impact of macrophage infiltration and the CPVL/MSR1 ratio (CM ratio) on patient prognosis. (G) A multivariate Cox model was employed to assess the impact of M2 macrophage infiltration and CM ratio on patient prognosis.