Fig. 1. Schematic for profiling the hPTM-mediated interactomes.

a Previous strategies that function in an in vitro setting (a test tube) or rely on prior genetic manipulation. b The nucleus-targeted cell-permeable histone-tail-based photoaffinity probes enable it to penetrate into cells and selectively accumulate in the nucleus. The hPTMs-mediated interactomes could be captured in native cells upon UV irradiation. Some elements of Fig. 1a, b were created in BioRender. Chu, G (2024) https://BioRender.com/u07k630.