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. 2025 Jan 7;8:0574. doi: 10.34133/research.0574

Fig. 7.

Fig. 7.

tRF-AspGTC activates the toll-like receptor 4 (TLR4)/MyD88/nuclear factor kappa B (NF-κB) pathway by stabilizing galectin-3 in VSMCs. (A) WB analysis of TLR4 immunoprecipitated with galectin-3 in VSMCs transfected with mimic-NC or tRF-AspGTC mimic. (B) WB analysis of NF-κB pathway proteins after tRF-AspGTC overexpression. (C) Quantitative analysis of (B); n = 3 per group. (D) WB analysis of TLR4/MyD88/NF-κB pathway proteins in VSMCs transfected with mimic-NC or tRF-AspGTC mimic and si-NC or si-LGALS3, followed by hydrogen peroxide treatment. (E) Quantitative analysis of (D); n = 3 per group. *P < 0.05; **P < 0.01; ***P < 0.001. IκBα, inhibitor of nuclear factor kappa-B alpha; p-IκBα, phosphorylated inhibitor of nuclear factor kappa-B alpha.