Table 4.

Multivariable regression analysis of factors associated with continuous frusemide infusion.

Variable	Unadjusted		Adjusted
	Odds Ratio (95 % CI)	p-value	Odds Ratio (95 % CI)	p-value
Time to frusemide initiation, day	1.70 (1.55, 1.87)	<0.001
Age, days	1.00 (1.00, 1.00)	<0.01	1.00 (1.00, 1.00)	0.07
PIM score	1.00 (0.99, 1.02)	0.54	1.01 (0.99, 1.03)	0.50
Congenital heart disease	1.70 (1.23, 2.33)	<0.01	1.67 (1.16, 2.40)	<0.01
Cardiopulmonary bypass	2.06 (1.53, 2.78)	<0.001
Mechanical ventilation prior to frusemide initiation	2.90 (1.65, 5.09)	<0.001	1.76 (0.86, 3.61)	0.12
Fluid overload at frusemide initiation, mL/kg	1.02 (1.00, 1.03)	0.01	1.01 (1.00, 1.03)	0.05
In children older than 1 month
Time to frusemide initiation, day	1.80 (1.62, 2.00)	<0.001
Age, days	1.00 (1.00, 1.00)	<0.01	1.00 (1.00, 1.00)	0.14
PIM score	1.00 (0.99, 1.02)	0.64	1.01 (0.99, 1.04)	0.27
Congenital heart disease	1.83 (1.31, 2.56)	<0.001	1.39 (0.90, 2.16)	0.14
Cardiopulmonary bypass	1.95 (1.41, 2.69)	<0.001
Mechanical ventilation prior to frusemide initiation	2.31 (1.30, 4.09)	<0.01	1.70 (0.67, 4.29)	0.26
Fluid overload at frusemide initiation, mL/kg	1.03 (1.01, 1.04)	<0.01	1.01 (0.99, 1.03)	0.29
AKI at PICU admission	2.86 (2.03, 4.04)	<0.001
AKI stage 2 or 3 at PICU admission	2.51 (1.75, 3.61)	<0.001
AKI at frusemide initiation	3.47 (2.40, 5.00)	<0.001
AKI stage 2 or 3 at frusemide initiation	4.84 (3.22, 7.27)	<0.001	4.58 (2.93, 7.16)	<0.001

PIM = Paediatric Index of Mortality, AKI = acute kidney injury, CI = confidence interval.