Table 1. Principal research studies investigating the impact of lipoic acid on testosterone levels in induced testicular toxicity conditions in males.
| Origin of the study (year) | Population of the study | Dose (mode) | Duration | Effect on testosterone | Reference |
|---|---|---|---|---|---|
| India (2006) | Male rats with adriamycin-ITT | 35 mg/kg per week (i.v.) | 10 weeks | (+) | [36] |
| Egypt (2010) | Male rats with cyclophosphamide-ITT | 35 mg/kg (orally) | 2 weeks | (+) | [37] |
| Egypt (2011) | Male rats with cadmium-ITT | 35 mg/kg (p.o) | 4 weeks | (+) | [38] |
| Egypt (2012) | Male rats with 4-tert-octylphenol-ITT | 50 mg/kg (p.o) 3 times a week | 5 weeks | (+) | [39] |
| Argentina (2013) | Male rats with pesticide-ITT | 25, 50, and 100 mg/kg (i.p.) | 5 weeks | (+) | [40] |
| Saudi Arabia (2013) | Male rats with Bisphenol A-ITT | 20 mg/kg (orally) | 2 weeks | (+) | [41] |
| Egypt (2014) | Male rats with acrylamide-ITT | 1% of basal diet (orally) | 3 weeks | (+) | [42] |
| Saudi Arabia (2014) | Male rats with bi-n-butyl phthalate-ITT | 20 mg/kg per day (orally) | 2 weeks | (+) | [43] |
| Turkey (2016) | Male rats with polychlorobiphenyl (aroclor 1260)-ITT | 25 mg/kg (orally) | 30 days | (+/–) | [34] |
| Saudi Arabia (2017) | Male rats with polychlorobiphenyl (aroclor 1260)-ITT | 35 mg/kg per day (orally) | 15 days | (+) | [35] |
| India (2017) | Male rats with carbimazole-ITT | 70 mg/kg per day (orally) | Embryonic days 9-21 | (+) | [44] |
| Turkey (2018) | Male rats with methotrexate-ITT | 100 mg/kg (i.p.) | Single dose | (+) | [45] |
| India (2018) | Male rats with arsenic-ITT | 70 mg/kg-3 times a week (i.p.) | 8 weeks | (+) | [46] |
| Iran (2019) | Male mice with radiation-ITD | 200 mg/kg | 2 days | (+/–) | [33] |
| Iran (2020) | Male rats with di-(2-ethylhexyl) phthalate-ITT | 20 mg/kg (p.o.) | 2 weeks | (+) | [47] |
| Egypt (2020) | Male rats with cyclosporine-ITT | 100 mg/kg | 45 days | (+) | [48] |
| Egypt (2020) | Male rats with ionizing radiation-ITD | 50 mg/kg (p.o.) | 1 week before and 3 days post-irradiation | (+/-) | [49] |
| Egypt (2021) | Male rats with carbimazole-ITT | 60 mg/kg per day (orally) | 30 days | (+) | [50] |
| Turkey (2021) | Male rats with doxorubicin-ITT | 50 mg/kg every other day (orally) | 28 days | (+) | [51] |
| Egypt (2022) | Male rats with silver nanoparticles-ITD | 100 mg/kg per day (orally) | 30 days | (+) | [52] |
ITT: Induced testicular toxicity, ITD: Induced testicular damage.