Fig. 4.

Interaction and competition among miRNAs and their target mRNAs in SJS/TEN with SOC. This figure illustrates the potential interactions and competitions between various miRNAs and their target mRNAs, as identified in plasma samples from patients with SJS/TEN with SOC. The study revealed that 8 miRNAs were up-regulated in these plasma samples, in addition to the previously identified miR-628-3p. Target mRNAs were confirmed by RT-qPCR, utilizing comprehensive gene expression analysis of mimics for each of the 9 miRNAs involved. Hexagons represent the eight up-regulated miRNAs in SJS/TEN with SOC. MiRNA-151a-3p was excluded because it showed no interaction with the examined target mRNAs. Green circles indicate the 11 target mRNAs examined in the context of all 9 miRNA mimics used in this study. Gray circles represent target mRNAs identified in preliminary experiments using mimics of 5 or 6 miRNAs.