Table 3. Risk Factor Analysis of Pediatric PTC Patients Who Underwent Total Thyroidectomy, Comparing Unilaterality and Bilaterality.

Characteristics		Unilaterality (n=42)	Bilaterality (n=18)	p value	Univariate		Multivariate
					OR (95% CI)	p value	OR (95% CI)	p value
Age (yr)		15.8±1.9	14.7±3.4	0.247	0.84 (0.67–1.06)	0.149
Female sex		36 (87.8)	11 (64.7)	0.064	0.26 (0.07–0.99)	0.050	0.59 (0.11–3.24)	0.544
Primary tumor size (cm)		2.5±1.0	3.8±2.5	0.053	1.56 (1.06–2.29)	0.024	1.47 (0.96–2.25)	0.077
Primary tumor size >2 cm		20 (48.8)	13 (76.5)	0.080	3.41 (0.95–12.24)	0.060
Preoperative ultrasonography finding
	Solid parenchyma	33 (97.1)	14 (100)	0.999	N/A
	Calcifications	24 (70.6)	10 (71.4)	0.999	1.04 (0.26–4.12)	0.954
	Irregular margins	15 (44.1)	8 (57.1)	0.529	1.69 (0.48–5.93)	0.414
	Taller than wide	2 (5.9)	1 (7.1)	0.999	1.23 (0.10–14.78)	0.870
	Hypoechoic	23 (67.6)	13 (92.9)	0.081	6.22 (0.72–53.76)	0.097
	Ipsilateral nodule present	7 (20.6)	5 (35.7)	0.294	2.14 (0.54–8.46)	0.277
	Contralateral nodule present	11 (32.4)	7 (50.0)	0.330	2.09 (0.59–7.45)	0.255
Final pathology*
	PTC, classical	26 (63.4)	8 (47.1)	0.380	0.51 (0.16–1.61)	0.253
	PTC diffuse sclerosing	6 (14.6)	3 (17.6)	0.999	1.25 (0.27–5.71)	0.773
	PTC, tall cell	6 (14.6)	1 (5.9)	0.661	0.37 (0.04–3.28)	0.368
	PTC, clear cell	2 (4.9)	2 (11.8)	0.573	2.60 (0.34–20.17)	0.361
	PTC, others	1 (2.4)	1 (5.9)	0.504	2.50 (0.15–42.44)	0.526
Multifocality		9 (22.0)	8 (47.1)	0.067	3.16 (0.95–10.55)	0.061
Gross ETE		7 (17.1)	5 (29.4)	0.307	2.02 (0.54–7.60)	0.296
Number of central LN metastasis		6.6±6.1	9.7±4.9	0.067	1.12 (1.01–1.24)	0.034	1.07 (0.95–1.21)	0.255
Number of lateral LN metastasis		11.6±6.3	20.3±9.6	0.013	1.06 (0.96–1.17)	0.258

OR, odds ratio; CI, confidence interval; PTC, papillary thyroid cancer; ETE, extrathyroidal extension; LN, lymph node.

Data are presented as mean±standard deviation or n (%).

^*PTC, others were not included since no patient had multifocal disease.