Table 4. Univariate and Multivariate Analyses of Risk Factors for Structural Recurrence in Pediatric Patients Who Underwent Total Thyroidectomy for PTC.
| Related factors | Univariate | Multivariate | |||
|---|---|---|---|---|---|
| HR (95% CI) | p value | HR (95% CI) | p value | ||
| Age (yr) | 0.95 (0.80–1.13) | 0.567 | |||
| Female sex | 0.91 (0.30–2.76) | 0.863 | |||
| Primary tumor size (cm) | 1.21 (0.98–1.51) | 0.083 | |||
| Primary tumor size >2 cm | 0.93 (0.37–2.36) | 0.879 | |||
| Final pathology | |||||
| PTC, classical | 0.39 (0.15–1.02) | 0.054 | |||
| PTC, diffuse sclerosing | 0.92 (0.31–3.70) | 0.920 | |||
| PTC, tall cell | 1.98 (0.65–6.02) | 0.230 | |||
| PTC, clear cell | 4.22 (1.21–14.72) | 0.024 | 4.43 (1.18–16.58) | 0.027 | |
| Multifocality | 4.64 (1.86–11.59) | 0.001 | 2.99 (1.08–8.27) | 0.035 | |
| Bilaterality | 1.91 (0.76–4.81) | 0.172 | |||
| Gross ETE | 4.41 (1.72–11.34) | 0.002 | 3.04 (1.06–8.72) | 0.038 | |
| Number of central LN metastasis | 1.05 (0.98–1.13) | 0.199 | |||
| Number of lateral LN metastasis | 1.08 (0.99–1.16) | 0.070 | |||
HR, hazard ratio; CI, confidence interval; PTC, papillary thyroid cancer; ETE, extrathyroidal extension; LN, lymph node.