Table 3.
The univariate and multivariate analysis of prognostic factors for 5-year RFS.
| Variables | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p-value | HR | 95%CI | p-value | |
| Age, yrs; ≤ 66, > 66 | 1.52 | 0.977–2.366 | 0.063 | |||
| Males/females | 1.08 | 0.701–1.686 | 0.095 | |||
| BMI, ≤ 22/ > 22 | 1.43 | 0.939–2.205 | 0.131 | |||
| Tumor location, right side/left side | 1.16 | 0.741–1.804 | 0.523 | |||
| Histology, well or moderate/others | 2.13 | 1.235–3.667 | 0.0065 | 1.59 | 0.89–2.82 | 0.011 |
| Depth of tumor invasion, T1–T2/T3–T4 | 6.73 | 3.103–14.59 | < 0.0001 | 3.51 | 1.58–7.80 | 0.020 |
| Lymph node metastasis, − / + | 3.17 | 2.051–4.910 | < 0.0001 | 2.24 | 1.38–3.62 | 0.001 |
| Lymph invasion, − / + | 3.31 | 2.099–5.235 | < 0.0001 | 1.89 | 1.15–3.10 | 0.011 |
| Venous invasion, − / + | 2.79 | 1.542–5.027 | 0.0007 | 1.50 | 0.79–2.82 | 0.206 |
| CEA level, normal /high | 2.07 | 1.350–3.183 | 0.0009 | 1.61 | 1.02–2.60 | 0.042 |
| CA19-9 level, normal /high | 3.04 | 1.695–4.367 | < 0.0001 | 1.39 | 0.83–2.33 | 0.209 |
| SIRI | 2.312 | 1.437–3.743 | 0.0006 | 1.60 | 1.04–2.65 | 0.045 |
BMI Body mass index, CEA Carcinoembryonic antigen, CA19-9 Carbohydrate antigen 19–9, SIRI Systemic inflammation response index.