Table 4.

The univariate and multivariate analysis of prognostic factors for 5-year OS.

Variables	Univariate			Multivariate
	HR	95%CI	p-value	HR	95%CI	p-value
Age, yrs; ≤ 66, > 66	1.52	0.677–2.366	0.098
Males/females	1.26	0.701–2.340	0.461
BMI, ≤ 22/ > 22	0.98	0.548–1.778	0.965
Tumor location, right side/left side	1.54	0.354–1.181	0.156
Histology, well or moderate/others	2.12	1.023–4.415	0.043	1.59	0.89–2.82	0.120
Depth of tumor invasion, T1–T2/T3–T4	3.05	1.360–6.823	0.002	3.51	0.69–3.80	0.244
Lymph node metastasis, − / +	2.42	1.344–4.357	0.003	2.24	1.28–2.96	0.041
Lymph invasion, − / +	2.55	1.385–4.700	0.002	1.89	0.76–2.97	0.236
Venous invasion, − / +	2.32	1.078–4.972	0.019	1.50	0.57–2.87	0.230
CEA level, normal /high	2.92	1.625–5.241	0.0004	1.61	1.40–4.66	0.002
CA19-9 level, normal /high	2.36	1.217–4.570	0.021	1.39	0.83–2.33	0.209
SIRI	2.11	1.122–3.965	0.018	1.60	1.03–2.43	0.048

BMI Body mass index, CEA Carcinoembryonic antigen, CA19-9 Carbohydrate antigen 19–9, SIRI Systemic inflammation response index.