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. 2025 Jan 6;4:261. doi: 10.1038/s43856-024-00668-8

Table 3.

Summary of cases who took an extended course of Paxlovid within the context of an acute re-infection

Case # Age, gender Date of COVID infection(s) Likely variant Initiation of Long COVID symptoms COVID vaccinations Date and length of extended course of Paxlovid Short-term improvement with Paxlovid Sustained improvement with Paxlovid Adverse effects of Paxlovid
12 41 y.o. woman Dec 2020 alpha Dec 2020 2021 (Mar, Apr), 2022 (Jan, Nov) Apr 2023 (10 d during acute infection) (returned to pre-reinfection baseline within 2 months) y
13 55 y.o. transgender person Mar 2020, Mar 2021, Dec 2022 original wild type, alpha, omicron Mar 2020 2021 (Feb, July, Oct), 2022 (Oct), 2023 (Apr) Dec 2022 (7.5 d during acute infection) (returned to pre-reinfection baseline within 3 weeks)