Table 1.
Baseline characteristics of trial participants
| Patient characteristic | SDE plus CAD-score arm (n = 1002) | SDE-only arm (n = 1006) |
|---|---|---|
| Age, mean (SD), y | 62.1 (12.1) | 62.6 (11.8) |
| Sex | ||
| Female | 558 (55.7) | 525 (52.2) |
| Male | 444 (44.3) | 481 (47.8) |
| Ethnicity | ||
| White | 975 (97.4) | 979 (97.5) |
| Other | 26 (2.5) | 25 (2.5) |
| Cardiovascular risk factors | ||
| Hypertension | 439 (43.8) | 432 (42.9) |
| Hyperlipidaemia | 299 (29.8) | 296 (29.4) |
| Family history of CAD | 231 (23.1) | 227 (22.7) |
| Current or past tobacco use | 621 (62.0) | 622 (61.8) |
| Diabetes mellitus | 94 (9.4) | 108 (10.7) |
| Body mass index, mean (SD), kg/m2 | 27.3 (5.4) | 27.3 (5.1) |
| Total burden of CV risk factorsa | ||
| No. of CV risk factors per patient, mean (SD) | 1.7 (1.1) | 1.7 (1.2) |
| Absence of any CV risk factors | 141 (14.1) | 152 (15.1) |
| Comorbidity | ||
| Peripheral artery or cerebrovascular disease | 65 (6.5) | 70 (7.0) |
| Chronic kidney disease | 17 (1.7) | 17 (1.7) |
| Risk scores | ||
| PTP, median (range)b | 13.0 (1–78) | 14.0 (1–69) |
| PTP≤5% (low risk) | 135 (13.5) | 137 (13.6) |
| PTP 5%–15% | 409 (40.8) | 397 (39.5) |
| PTP > 15% | 458 (45.7) | 472 (46.9) |
| Type of angina | ||
| Typical angina (cardiac) | 252 (25.1) | 247 (24.6) |
| Atypical angina (possible cardiac) | 301 (30.0) | 271 (26.9) |
| Non-anginal chest pain (non-cardiac) | 350 (34.9) | 379 (37.7) |
| Dyspnoea on exertion | 99 (9.9) | 109 (10.8) |
| Systolic blood pressure, mean (SD) | 135.8 (18.5) | 135.3 (18.5) |
| Diastolic blood pressure, mean (SD) | 84.5 (10.0) | 84.5 (10.6) |
| Use of relevant CV medications | ||
| Antiplatelet medication | 173 (17.3) | 175 (17.4) |
| Lipid-lowering medication | 299 (29.8) | 296 (29.4) |
| Antianginal medication | 59 (5.9) | 90 (8.9) |
| Anticoagulant medication | 47 (4.7) | 57 (5.7) |
| Seattle Angina Questionnaire, mean (SD) | ||
| Physical limitation score | 83.4 (18.8) | 82.6 (19.3) |
| Angina stability score | 50.6 (22.5) | 51.1 (22.8) |
| Angina frequency score | 74.9 (17.0) | 74.0 (17.2) |
| Treatment satisfaction score | 86.2 (16.8) | 85.7 (16.3) |
| Quality of life score | 53.5 (23.1) | 54.0 (23.4) |
| EQ-5D-5L, mean (SD) | ||
| Summary score | 0.85 (0.18) | 0.86 (0.17) |
CAD, coronary artery disease; CV, cardiovascular; PTP, pre-test probability; SD, standard deviation; SDE, standard diagnostic examination.
aRisk factors included are hypertension, hyperlipidaemia, family history of CAD, diabetes mellitus, and tobacco use.
bPTP according to 2019 ESC guidelines.