Table E8.
Genomic differences between tumors that did and did not metastasize to the brain
| Gene | Mutational analysis, number altered |
||
|---|---|---|---|
| Brain metastasis cohort (N = 77) | No brain metastasis cohort (N = 1008) | Q value | |
| TP53 | 45 (58) | 358 (36) | .002 |
| NKX2-1 | 8 (10) | 34 (3.3) | .041 |
| RB1 | 5 (6.5) | 22 (2.2) | .19 |
| ERBB2 | 5 (6.5) | 32 (3.2) | .53 |
| MYC | 5 (6.5) | 32 (3.2) | .53 |
| SETD2 | 5 (6.5) | 45 (4.5) | .88 |
| CDK4 | 5 (6.5) | 47 (4.7) | .88 |
| STK11 | 11 (14) | 123 (12) | .88 |
| EGFR | 21 (27) | 56 (31) | .88 |
| RBM10 | 9 (12) | 145 (14) | .88 |
| TERT | 6 (7.8) | 68 (6.7) | .88 |
| KRAS | 29 (38) | 359 (36) | .89 |
| MDM2 | 5 (6.5) | 63 (6.3) | .93 |
| CDKN2A | 5 (6.5) | 70 (6.9) | 1 |
Bold type indicates statistical significance.