Table 3.  Minimal clinically important differences (MCIDs) in physical assessment of SMA.
Total (n=26) |
SMA type 3 (n=15) |
SMA type 2 (n=11) |
Non-ambulatory (n=17) | Ambulatory (n=9) |
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SEm | 1/2 SD | 1/3 SD | SEm | 1/2 SD | 1/3 SD | SEm | 1/2 SD | 1/3 SD | SEm | 1/2 SD | 1/3 SD | SEm | 1/2 SD | 1/3 SD | |
6MWT, m | 58.38 | 75.37 | 50.25 | 58.38 | 75.37 | 50.25 | N/A | N/A | N/A | N/A | N/A | N/A | 60.15 | 77.66 | 51.77 |
HFMSE | 4.71 | 11.63 | 7.75 | 4.66 | 11.50 | 7.67 | 2.12 | 5.24 | 5.40 | 2.19 | 5.41 | 3.60 | 1.22 | 3.01 | 2.01 |
RULM | 3.25 | 7.13 | 4.75 | 3.16 | 6.92 | 4.62 | 0.63 | 1.38 | 0.92 | 1.60 | 3.52 | 2.35 | 0.69 | 1.51 | 1.00 |
Rt grip, N | 10.93 | 18.21 | 12.14 | 12.88 | 21.47 | 14.31 | 1.21 | 2.02 | 1.35 | 3.87 | 6.46 | 4.31 | 14.11 | 23.51 | 15.68 |
Lt grip, N | 9.86 | 12.73 | 8.48 | 11.56 | 14.92 | 9.95 | 1.92 | 2.48 | 1.65 | 3.13 | 4.04 | 2.70 | 11.86 | 15.31 | 10.21 |
Rt Palmar pinch, N | 5.42 | 5.44 | 3.63 | 6.46 | 6.49 | 4.32 | 0.90 | 0.90 | 0.60 | 1.91 | 1.92 | 1.28 | 6.85 | 6.88 | 4.58 |
Lt Palmar pinch, N | 4.73 | 4.75 | 3.17 | 5.52 | 5.54 | 3.70 | 0.65 | 0.65 | 0.43 | 1.75 | 1.76 | 1.17 | 5.76 | 5.78 | 3.86 |
Rt Key pinch, N | 11.96 | 11.14 | 7.43 | 13.93 | 12.98 | 8.65 | 2.17 | 2.02 | 1.35 | 6.38 | 5.94 | 3.96 | 13.83 | 12.88 | 8.59 |
Lt Key pinch, N | 8.66 | 8.07 | 5.38 | 10.15 | 9.45 | 6.30 | 2.17 | 1.43 | 0.96 | 4.48 | 4.17 | 2.78 | 10.45 | 9.73 | 6.49 |
Rt grip, N/kg | 0.22 | 0.37 | 0.25 | 0.28 | 0.46 | 0.31 | 0.05 | 0.08 | 0.05 | 0.08 | 0.13 | 0.09 | 0.25 | 0.41 | 0.27 |
Lt grip, N/kg | 0.26 | 0.33 | 0.22 | 0.32 | 0.41 | 0.27 | 0.07 | 0.10 | 0.06 | 0.09 | 0.12 | 0.08 | 0.26 | 0.34 | 0.23 |
Rt Palmar pinch, N/kg | 0.13 | 0.13 | 0.09 | 0.16 | 0.16 | 0.11 | 0.08 | 0.08 | 0.06 | 0.07 | 0.07 | 0.05 | 0.15 | 0.15 | 0.10 |
Lt Palmar pinch, N/kg | 0.11 | 0.11 | 0.07 | 0.13 | 0.13 | 0.08 | 0.05 | 0.05 | 0.03 | 0.04 | 0.04 | 0.03 | 0.10 | 0.10 | 0.07 |
Rt Key pinch, N/kg | 0.26 | 0.25 | 0.16 | 0.29 | 0.27 | 0.18 | 0.16 | 0.15 | 0.10 | 0.14 | 0.13 | 0.09 | 0.20 | 0.18 | 0.12 |
Lt Key pinch, N/kg | 0.20 | 0.18 | 0.12 | 0.29 | 0.27 | 0.14 | 0.11 | 0.10 | 0.07 | 0.10 | 0.09 | 0.06 | 0.20 | 0.18 | 0.12 |
Rt, right; Lt, left.