Table 2.

Common factors reported that constitute potential barriers to and enablers of playing video games experienced by people with amyotrophic lateral sclerosis and motor neuron disease or others with similar motor impairment issues.

Technology and references		Potential barriers	Potential enablers
Customized information and communications technology for communication and control of computer systems (categories: quantitative, quantitative and qualitative, qualitative, and review research)
	Nuyujukian et al [37] Uma et al [38] Holz et al [39] Scherer et al [40] Cooper et al [43] Janthanasub and Ophapasai [44] Jaramillo-Gonzalez et al [45] Jarosiewicz et al [46,47] Kageyama et al [48] Käthner et al [49,50] Longatelli et al [51] Mott [52] Peters et al [53] Plotkin et al [54] Pousada et al [55] Sakamaki et al [56] Silversmith et al [57] Simeral et al [58] Simatis et al [59] Taherian et al [62] Isabela Lopes et al [63] Wallock and Cerny [64] Whittington et al [66] Wolpaw et al [67] Won et al [68] Zisk et al [69] Yao et al [70] Jamil et al [90] Kellmeyer et al [91] Pasqualotto et al [92] Linse et al [93] Pinto et al [95] Holz et al [98] Martisius and Damasevicius [99] Pedrocchi et al [100] Karlsson et al [101] Thais Pousada et al [102] Metzler-Baddeley et al [103] Dontje et al [105] Canella et al [106] Liberati et al [107] Versalovic et al [108] McFarland and Wolpaw [96] Judge et al [109]	Varied or limited technology performance that limits ease of use, including time delays when typing or interacting with software and other difficulties using technology; lack of power; poor internet access; and weight, portability, or body fitting issues	Increased ability of the user to control and interact with hardware and software to undertake a range of daily life activities including communication
	Mackenzie et al [1] Lancioni et al [9] Hobson et al [36] Holz et al [39] Lancioni et al [41] Jaramillo-Gonzalez et al [45] Käthner et al [49] Longatelli et al [51] Plotkin et al [54] Pousada et al [55] Simmatis et al [59] Whittington et al [66] Wolpaw et al [67] Jamil et al [90] Pinto et al [95] Holz et al [98] Martišius and Damaševičius [99] Pedrocchi et al [100] Karlsson et al [101] Metzler-Baddeley et al [103] Canella et al [106] Liberati et al [107] Judge et al [109]	Difficulties using technology due to limited physical movement and strength, fatigue, poor vision, and other similar issues associated with disease or disability	Increased ability of the user to restore functionality for communication and control of hardware and software through more accessible and customized technology that meets their physical and related needs
	Mackenzie et al [1] Hobson et al [36] Peters et al [53] Pousada et al [55] Silversmith et al [57] Wolpaw et al [67] Sharma et al [79] Jamil et al [90] Kellmeyer et al [91] Neto et al [94] Pinto et al [95] Pousada et al [102] Metzler-Baddeley et al [103] Canella et al [106] Liberati et al [107] Versalovic et al [108] McFarland and Wolpaw [96] Judge et al [109]	Issues with affordability, availability, community awareness, skills to use technology, support from others, and ability of technology to meet changing abilities due to disease progression	Increased ability of the users to access and use a range of devices and technology that meet their needs with support from others in the community and professionals
Video game software and hardware (categories: lived experience stories, news, or information resources; guidelines; quantitative and qualitative research; and qualitative research)
	AbleGamers [15,16] Game Accessibility Guidelines [21] Microsoft [22] Compañ-Rosique et al [110] Hellwig et al [104] AbleGamers [71,72] Microsoft [85] AbleGamers [86,87] Bayliss [88] Metzler-Baddeley et al [103] Microsoft [111] Anhong et al [112]	Difficulty with game playability, including difficulty level, speed, menus, graphical or hardware interfaces, a lack of alternatives for gameplay, a lack of engaging game design, and problems with software interfaces for providing feedback and social interactions	Increased ability of the user to control and interact with game software and enjoy gameplay more due to having multiple options for interfaces and interactions, including those sensitive to fatigue or movement and mobility difficulties, use of sliders and circular meters and devices that do not require the use of hands, or configurable speed or remappable controls
	AbleGamers [15,16] Game Accessibility Guidelines [21] Microsoft [22] Hellwig et al [104] AbleGamers [71,72] Barrett Centre for Technology Innovation [74] Reddit [80] Dall [81] Klassen [82] SpecialEffect [83] Microsoft [85] AbleGamers [86,87] Microsoft [111]	Difficulty with the physical requirements for interacting with games (including difficulty with console controllers and movement and mobility, such as limited hand or speech function)	Increased ability of the user to restore functionality for control of game hardware and software through more accessible and customized technology that meets their physical and related needs