Skip to main content
. 2025 Jan 1;16(3):750–764. doi: 10.7150/jca.101050

Figure 3.

Figure 3

HIF-1α activates the P-PI3K/P-AKT, SOX2/OCT4 and MMP2/MMP9 signaling pathways in GBM. (A) Western blot analysis of P-PI3K, PI3K, P-AKT, and AKT protein expression in GBM; (B) Expression levels of P-PI3K and PI3K proteins graphed; (C) Expression levels of P-AKT and AKT proteins graphed; (D) Western blot analysis of SOX2 and OCT4 protein expression in GBM; (E) Expression levels of SOX2 protein graphed; (F) Expression levels of OCT4 protein graphed; (G) Western blot analysis of MMP2 and MMP9 protein expression in GBM; (H) Expression levels of MMP2 protein graphed; (I) Expression levels of MMP9 protein graphed. Data are presented as mean ± standard deviation, and differences between two groups were analyzed using an unpaired t-test. *P <0.05, **P <0.01, ***P <0.001, ****P <0.0001.