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. 2025 Jan 1;21(2):614–631. doi: 10.7150/ijbs.103032

Figure 5.

Figure 5

LPCAT1 can influence the expression of FBXW7 by regulating the NF-κB signaling pathway. A. Venn diagram of upregulated genes from the differentially expressed genes in sh-LPCAT1 and the gene sets of fatty acids and ubiquitin from GSEA. B, C. Analysis of differentially expressed genes from transcriptomic sequencing of sh-LPCAT1 shows that the NF-κB signaling pathway and the process of ubiquitination are enhanced after LPCAT1 knockdown. D, E. Verification of the expression of the NF-κB signaling pathway and FBXW7 in786-O and A-498, after LPCAT1 knockdown. F, G. Treatment of 786-O and A-498 cells with 0.25μM, 0.50μM, 0.75μM, and 1.00μM of the NF-κB signaling pathway inhibitor IKK-16 to verify the changes in FBXW7 protein expression when the NF-κB signaling pathway is inhibited.