TABLE 2.
Overview of median MICs, MBCs, BPCs, and MBICs (in µg/mL) of the different antibiotics for the 18 clinical PJI isolates investigateda
| MIC | MBC | BPC | MBIC | |
|---|---|---|---|---|
| Oxacillin | ||||
| S. aureus SAU060122 | 0.25 | 4 | 0.5 | >1,024 |
| S. lugdunensis CCUG 52060 | 1 | 2 | 1 | >1,024 |
| S. capitis subsp. capitis CCUG 39451 | 0.25 | 0.5 | 0.5 | >1,024 |
| S. aureus A1 | 4 | 32 | 16 | >1,024 |
| S. aureus IDRL-9783 | 2 | 16 | 16 | >1,024 |
| S. aureus IDRL-10982 | 0.25 | 2 | 0.25 | >1,024 |
| S. epidermidis UZ220909-2978-1 | 8 | 64 | 32 | >1,024 |
| S. epidermidis HD05-1 ST2 | 64 | 512 | 32 | >1,024 |
| S. epidermidis HD04-1 ST5 | 16 | 256 | 64 | >1,024 |
| Rifampicin | ||||
| S. aureus SAU060122 | 0.001953 | 0.25 | 0.03125 | >32 |
| S. lugdunensis CCUG 52060 | 0.000977 | 0.25 | 0.015625 | 0.5 |
| S. capitis subsp. capitis CCUG 39451 | 0.003906 | 0.25 | 0.03125 | 0.125 |
| S. aureus A1 | 0.001953 | 0.125 | 0.0078125 | >32 |
| S. aureus IDRL-9783 | 0.0078125 | 0.125 | 0.015625 | >32 |
| S. aureus IDRL-10982 | 0.003906 | 0.125 | 0.015625 | 0.0625 |
| S. epidermidis UZ220909-2978-1 | 0.0078125 | 0.0625 | 0.015625 | >32 |
| S. epidermidis HD05-1 ST2 | 32 | 32 | >32 | >32 |
| S. epidermidis HD04-1 ST5 | 0.025 | 0.5 | 0.03125 | >32 |
| C. acnes CCUG 48138 | 0.03125 | 1 | 0.015625 | >32 |
| Doxycyclin | ||||
| S. aureus SAU060122 | 0.25 | 4 | 0.5 | 256 |
| S. lugdunensis CCUG 52060 | 0.125 | 8 | 0.125 | 128 |
| S. capitis subsp. capitis CCUG 39451 | 4 | 64 | 8 | 128 |
| S. aureus A1 | 16 | 128 | 8 | 256 |
| S. aureus IDRL-9783 | 0.25 | 8 | 0.25 | 128 |
| S. aureus IDRL-10982 | 0.25 | 8 | 0.5 | 128 |
| S. epidermidis UZ220909-2978-1 | 0.125 | 4 | 0.125 | 32 |
| S. epidermidis HD05-1 ST2 | 2 | 32 | 1 | 128 |
| S. epidermidis HD04-1 ST5 | 0.25 | 4 | 0.25 | 128 |
| S. agalactiae CCUG 49100 | 8 | 128 | 8 | 1,024 |
| E. faecalis CCUG 35182 | 4 | 128 | ND | ND |
| C. acnes CCUG 48138 | 2 | 16 | 0.25 | 256 |
| Cefazolin | ||||
| S. aureus SAU060122 | 0.25 | 32 | 0.5 | ND |
| S. lugdunensis CCUG 52060 | 0.5 | 8 | 1 | ND |
| S. capitis subsp. capitis CCUG 39451 | 1 | 1 | 2 | ND |
| S. aureus A1 | 1 | 32 | 4 | ND |
| S. aureus IDRL-9783 | 2 | 32 | 4 | ND |
| S. aureus IDRL-10982 | 0.5 | 8 | 4 | ND |
| S. epidermidis UZ220909-2978-1 | 4 | 64 | 8 | ND |
| S. epidermidis HD05-1 ST2 | 64 | 256 | 128 | ND |
| S. epidermidis HD04-1 ST5 | 4 | 64 | 4 | ND |
| S. agalactiae CCUG 49100 | 0.25 | 0.5 | 0.25 | ND |
| E. faecalis CCUG 35182 | 32 | 1024 | ND | ND |
| C. acnes CCUG 48138 | 0.5 | 8 | 0.25 | ND |
| E. coli UZ300822-0412-1 | 8 | 32 | 32 | ND |
| E. coli UZ290822-1777-1 | 8 | 64 | 32 | ND |
| P. aeruginosa UZ230201-3568-1 | >1,024 | >1,024 | ND | ND |
| P. aeruginosa UZ230406-3644-1 | >1,024 | >1,024 | ND | ND |
| Candida parapsilosis UZ220929-2760-1 | >1,024 | >1,024 | ND | ND |
| Candida albicans UZ221012-3305-1 | >1,024 | >1,024 | ND | ND |
| Amoxicillin | ||||
| S. agalactiae CCUG 49100 | 0.0625 | 0.0625 | 0.0625 | >1,024 |
| E. faecalis CCUG 35182 | 4 | 4 | ND | ND |
| C. acnes CCUG 48138 | 0.25 | 4 | 0.0625 | 16 |
| Vancomycin | ||||
| S. agalactiae CCUG 49100 | 0.5 | 64 | 1 | >1,024 |
| E. faecalis CCUG 35182 | 1 | 1 | ND | ND |
| Ceftriaxon | ||||
| S. agalactiae CCUG 49100 | 0.03125 | 0.25 | 0.0625 | >1,024 |
| E. faecalis CCUG 35182 | 512 | >1,024 | ND | ND |
| C. acnes CCUG 48138 | 0.5 | 1 | 0.125 | 8 |
| Ciprofloxacin | ||||
| E. coli UZ300822-0412-1 | 128 | >1,024 | 256 | >1,024 |
| E. coli UZ290822-1777-1 | 256 | >1,024 | 256 | >1,024 |
| P. aeruginosa UZ230201-3568-1 | 16 | 16 | 8 | >1,024 |
| P. aeruginosa UZ230406-3644-1 | 0.25 | 1 | 0.25 | >1,024 |
| Fluconazole | ||||
| C. parapsilosis UZ220929-2760-1 | >512 | >512 | ND | ND |
| C. albicans UZ221012-3305-1 | >512 | >512 | ND | ND |
a
ND, not determined.