Fig. 8.

CEBPB and USP14 regulated cardiac Function by modulating NLRP3 inflammasome in vivo. (A) Short-term survival curve after myocardial infarction and the indicated treatments. (B) Representative short-axis M-mode echocardiograms of the left ventricle at baseline and day 21 in the HFD/STZ-induced diabetic mice with myocardial infarction groups. Left ventricular function was assessed by measurements of ejection fraction, LV fractional shortening, end diastolic volume, and end systolic volume. (C) Representative endothelial CD31 staining at the infarction border zone sections. (D) Representative images and quantitative infarct size in Masson’s trichrome stained mice hearts on day 21 after MI (n = 6 mice/group). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. These experiments were repeated independently at least three times with similar results