Table 3. Longitudinal test characteristics using cervical intraepithelial neoplasia grade 2 or worse (CIN2+) as outcome at 3, 5, 7, and 10 years of follow-up.
| Cumulative counts of CIN2+ at follow-up by baseline results | Test characteristics for CIN2+ | |||||||
|---|---|---|---|---|---|---|---|---|
| Cytology | HPV | Cytology | HPV | |||||
| Negative | Positive | Negative | Positive | Sensitivity (95% CI) | Specificity (95% CI) | Sensitivity (95% CI) | Specificity (95% CI) | |
| Baseline | 7,122 | 139 | 6,766 | 392 | ||||
| 3 years | 4 | 20 | 1 | 49 | 84.5 (75.6, 90.5) |
98.2 (98.1, 98.2) |
98.1 (87.8, 99.7) |
94.3 (94.3, 94.4) |
| 5 years | 21 | 20 | 3 | 61 | 50.9 (46.7, 55.1) |
97.8 (97.8, 97.9) |
95.7 * (91.9, 97.8) |
92.2 (92.2, 92.3) |
| 7 years | 41 | 21 | 8 | 63 | 35.9 (33.0, 38.8) |
98.1 (98.1, 98.2) |
89.6 * (86.4, 92.1) |
91.2 (91.1, 91.2) |
| 10 years | 57 | 21 | 15 | 63 | 28.6 (25.0, 32.5) |
97.9 (97.7, 98.0) |
82.1 * (78.5, 85.3) |
92.2 (91.9, 92.4) |
*P-values for test of difference of proportions, compared to sensitivity of cytology at 5 years all P < 0.0001.
HPV, human papillomavirus; CI, confidence interval.