Summary of findings 2. Summary of findings table ‐ Cytisine compared to placebo for nicotine vaping cessation.

Cytisine compared to placebo for nicotine vaping cessation
Patient or population: nicotine vaping cessation Setting: Any (USA) Intervention: cytisine Comparison: placebo
Outcomes	Anticipated absolute effects* (95% CI)		Relative effect (95% CI)	№ of participants (studies)	Certainty of the evidence (GRADE)	Comments
	Risk with placebo	Risk with cytisine
Vaping cessation at 6 months or longer ‐ not reported	‐	‐	‐	‐	‐	No studies reported this outcome.
Change in combustible tobacco use at 6 months or longer ‐ not reported	‐	‐	‐	‐	‐	No studies reported this outcome.
Number of participants reporting SAEs follow‐up: 4 months	Not pooled	Not pooled	Not pooled	159 (1 RCT)	⊕⊕⊝⊝ Lowa	We did not calculate relative or absolute effects as there were no events across study arms.
*The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: confidence interval
GRADE Working Group grades of evidence High certainty: we are very confident that the true effect lies close to that of the estimate of the effect. Moderate certainty: we are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different. Low certainty: our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect. Very low certainty: we have very little confidence in the effect estimate: the true effect is likely to be substantially different from the estimate of effect.
See interactive version of this table: https://gdt.gradepro.org/presentations/#/isof/isof_question_revman_web_451185324505541376.

^a Downgraded two levels due to imprecision. No events were reported across study arms.