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. Author manuscript; available in PMC: 2026 Jan 7.
Published in final edited form as: Biochemistry. 2024 Dec 9;64(1):138–155. doi: 10.1021/acs.biochem.4c00558

Figure 9.

Figure 9.

Recovery of plasma membrane localization of GFP-H-Ras in MDCK cells treated with lovastatin using various isoprenoids. All cells were treated with lovastatin (30 μM) for 24 h except the untreated sample. Where indicated, cells were supplemented with the isoprenoid indicated after 18 h of statin treatment and incubation continued for an additional 6 h. (A) Untreated cells; (B) Cells treated with statin only for 24 h; (C) Cells treated with statin and FPP (30 μM); (D) Cells treated with statin and FOH (30 μM); (E) Cells treated with statin and GGPP (30 μM); (F) Cells treated with statin and C15AlkOPP (30 μM); (G) Cells treated with statin and C15AlkOH (30 μM); (H) Cells treated with statin and C15hAlkOPP (30 μM). For each column, the GFP channel showing the GFP-H-Ras is at the top, the nuclear stain (Hoechst 34580) in the middle and the merged channels at the bottom.