Table 2.

Adverse events by grade

	All grades (%)	Grade 3/4 (%)
Leukopenia	39 (38)	16 (16)
Neutropenia	49 (48)	37 (36)
Febrile neutropenia	7 (7)	7 (7)
Anemia	5 (5)	1 (1)
Thrombocytopenia	3 (3)	0 (0)
AST increased	3 (3)	2 (2)
ALT increased	3 (3)	2 (2)
Bilirubin increased	3 (3)	1 (1)
Creatinine increased	1 (1)	0 (0)
Anorexia	62 (60)	9 (9)
Nausea	21 (20)	1 (1)
Vomiting	4 (4)	0 (0)
Diarrhea	30 (29)	5 (5)
Mucositis oral	12 (12)	1 (1)
Fatigue	26 (25)	2 (2)
Alopecia	42 (41)	–

Adverse event grades were determined using the Common Terminology Criteria for Adverse Events version 5.0

AST aspartate transferase, ALT alanine transaminase