Table 3.
Summary of immunophenotyping results from the spleen (C57BL/6J, BALB/cJ, and J:ARC[S]), small and large intestines, and sera (C57BL/6J) during Cm infection.
| DPC | strain | tissue | Description |
|---|---|---|---|
| Spleen | ↑ monocytes. ↓ B cells. CD8+ T cells: ↑Teffector | ||
| SI | ILC3: ↑ CCR6 and T-bet expression | ||
| 14 | B6 | LI | ↑ total CD45+ and Ly6G+ cells CD4+ T cells: ↑ Teffector, ↓ Tregulatory Cytokines: ↑ IFNγ (CD4+ T cells); ↑ IL-17A and IL-22 (CD4+ T cells and ILC3) |
| Serum | ↑ IL-6 | ||
| C | Spleen | ↓ macrophages. CD4+ T cells: ↓ overall | |
| S | Spleen | CD8+ T cells: ↓Teffector, ↑ naive | |
| Spleen | ↑ monocytes. ↓ B cells. CD8+ T cells: ↑ Teffector | ||
| SI | ILC3: ↑ T-bet expression | ||
| 63 | B6 | LI | ↑ total CD45+ and Ly6G+ cell CD4+ T cells: ↑ Teffector (↑ T-bet+ and RORgt+) ILCs: ↑ overall T-bet+; ILC3s ↑ T-bet+ and CCR6+ Cytokines: ↑ IFNγ and IL-17A (CD4+ T cells); ↑ IL-22 and GM-CSF (CD4+ T cells and ILC3) |
| Serum | ↑ IL-4, IL-12p70 | ||
| C | Spleen | ↑ monocytes; CD8+ T cells: ↑Tcentral memory | |
| S | Spleen | ↑ monocytes; CD4+ T cells: ↑ Tcentral memory, ↑ Teffector memory, ↓naïve |
B6, C57BL/6J; C, BALB/cJ; S, J:ARC(S); DPC, days postcohousing; LI, large intestine; SI, small intestine.