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. 1998 Aug 3;17(15):4283–4290. doi: 10.1093/emboj/17.15.4283

A mammalian two pore domain mechano-gated S-like K+ channel.

A J Patel 1, E Honoré 1, F Maingret 1, F Lesage 1, M Fink 1, F Duprat 1, M Lazdunski 1
PMCID: PMC1170762  PMID: 9687497

Abstract

Aplysia S-type K+ channels of sensory neurons play a dominant role in presynaptic facilitation and behavioural sensitization. They are closed by serotonin via cAMP-dependent phosphorylation, whereas they are opened by arachidonic acid, volatile general anaesthetics and mechanical stimulation. We have identified a cloned mammalian two P domain K+ channel sharing the properties of the S channel. In addition, the recombinant channel is opened by lipid bilayer amphipathic crenators, while it is closed by cup-formers. The cytoplasmic C-terminus contains a charged region critical for chemical and mechanical activation, as well as a phosphorylation site required for cAMP inhibition.

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Selected References

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