Table 2.
Association of SII with all-cause and cardiovascular mortality in adults with depression from NHANES 2005–2018
| Model 1 | Model 2 | Model 3 | |||||||
|---|---|---|---|---|---|---|---|---|---|
| HR(95%CI) | P value | HR(95%CI) | P value | HR(95%CI) | P value | ||||
| All-cause mortality | |||||||||
| Per 100 increment | 1.05(1.02,1.09) | 0.001 | 1.05(1.02,1.08) | 0.003 | 1.05(1.02,1.08) | 0.003 | |||
| Quartiles | |||||||||
| Q1 | 2.16(1.30,3.60) | 0.003 | 2.05(1.25,3.37) | 0.004 | 1.94(1.18,3.19) | 0.01 | |||
| Q2 | ref | ref | ref | ||||||
| Q3 | 2.09(1.27,3.44) | 0.004 | 1.86(1.12,3.10) | 0.02 | 1.88(1.16,3.07) | 0.01 | |||
| Q4 | 2.28(1.41,3.68) | < 0.001 | 2.16(1.34,3.47) | 0.002 | 2.07(1.30,3.28) | 0.002 | |||
| P for trend | 0.003 | 0.01 | 0.01 | ||||||
| CVD mortality | |||||||||
| Per 100 increment | 1.08(1.05,1.12) | < 0.001 | 1.06(1.02,1.10) | 0.003 | 1.06(1.02,1.10) | 0.004 | |||
| Quartiles | |||||||||
| Q1 | 2.32(0.89,5.99) | 0.08 | 2.09(0.87,5.02) | 0.10 | 1.82(0.76,4.34) | 0.18 | |||
| Q2 | ref | ref | ref | ||||||
| Q3 | 4.02(1.81,8.91) | < 0.001 | 3.46(1.55,7.73) | 0.002 | 3.11(1.36,7.13) | 0.01 | |||
| Q4 | 3.10(1.30,7.41) | 0.01 | 3.14(1.30,7.60) | 0.01 | 2.79(1.14,6.85) | 0.03 | |||
| P for trend | 0.01 | 0.004 | 0.01 | ||||||
Abbreviations SII, Systemic Immune-Inflammation; CVD, cardiovascular disease; PIR, poverty income ratio; BMI, body mass index; NHANES, National Health and Nutrition Examination Survey; HR, hazard ratio; CI, confidence interval
Model 1: no adjusted
Model 2: adjusted for age and sex
Model 3: further adjusted for race, education level, marital status, PIR, BMI, smoking status, drinking status, diabetes, hypertension, coronary heart disease, cancer and antidepressant use