Table 3.

Threshold effect analysis of SII on all-cause mortality using the two-piecewise regression model

	Model 1			Model 2		Model 3
	HR(95 CI%)	P value		HR(95 CI%)	P value	HR(95 CI%)	P value
< threshold value	1.07(1.04,1.09)		< 0.001	1.06(1.03,1.09)	< 0.001	1.06(1.03,1.09)	< 0.001
≥ threshold value	0.77(0.57,1.05)		0.10	0.81(0.60,1.10)	0.17	0.85(0.65,1.13)	0.26

Abbreviations SII, Systemic Immune-Inflammation; CVD, cardiovascular disease; PIR, poverty income ratio; BMI, body mass index; NHANES, National Health and Nutrition Examination Survey; HR, hazard ratio; CI, confidence interval

Model 1: no adjusted

Model 2: adjusted for age and sex

Model 3: further adjusted for race, education level, marital status, PIR, BMI, smoking status, drinking status, diabetes, hypertension, coronary heart disease, cancer and antidepressant use