Table 1.
Baseline Characteristics of the Participants Based on Different eGFR and Hs-CRP Groups
| Variables | Total (N=16,516) | High eGFR/Low hs-CRP (N=6,915) | High eGFR/High hs-CRP (N=3,154) | Low eGFR/Low hs-CRP (N=4,638) | Low eGFR/High hs-CRP (N=1,809) | P value |
|---|---|---|---|---|---|---|
| Age, mean±SD, years | 55.71±10.48 | 53.53±9.76 | 55.53±9.97 | 57.39±10.77 | 60.08±11.13 | <0.0001 |
| Current smoker (%) | 5,187 (31.4) | 2,250 (32.5) | 839 (26.6) | 1,557 (33.6) | 541 (29.9) | <0.0001 |
| Current alcohol drinker (%) | 2,515 (15.2) | 1,052 (15.2) | 352 (11.2) | 847 (18.3) | 264 (14.6) | <0.0001 |
| Hypertension (%) | 10,457 (63.3) | 4,025 (58.2) | 2,017 (64.0) | 3,102 (66.9) | 1,313 (72.6) | <0.0001 |
| SBP, mean±SD, mmHg | 139.03±21.13 | 136.43±20.62 | 138.88±20.95 | 141.31±21.09 | 143.35±22.10 | <0.0001 |
| DBP, mean±SD, mmHg | 87.13±11.87 | 86.16±11.56 | 86.74±11.69 | 88.08±12.02 | 89.06±12.53 | <0.0001 |
| FBG, mean±SD, mmol/L | 8.89±2.81 | 8.68±2.69 | 8.97±2.71 | 9.04±2.90 | 9.16±3.08 | <0.0001 |
| HR, mean±SD, bpm | 77.12±11.30 | 77.18±11.29 | 77.44±11.36 | 76.50±10.96 | 77.95±11.96 | 0.0002 |
| TC, mean±SD, mmol/L | 5.27±1.40 | 5.30±1.24 | 5.35±1.54 | 5.19±1.44 | 5.23±1.62 | <0.0001 |
| LDL-C, mean±SD, mmol/L | 2.62±1.19 | 2.64±1.08 | 2.50±1.70 | 2.65±0.91 | 2.63±1.13 | <0.0001 |
| HDL-C, mean±SD, mmol/L | 1.52±0.47 | 1.56±0.49 | 1.50±0.47 | 1.51±0.42 | 1.47±0.53 | <0.0001 |
| UA, mean±SD, umol/L | 284.24±87.38 | 276.42±84.70 | 277.56±84.67 | 291.57±87.35 | 307.01±96.27 | <0.0001 |
| Serum creatinine, mean±SD, umol/L | 91.75±42.78 | 75.76±13.68 | 74.25±15.20 | 117.91±54.39 | 116.27±64.37 | <0.0001 |
| eGFR, mean±SD, mL/min/1.73m2 | 69.88±24.71 | 83.15±18.55 | 85.65±25.48 | 47.80±9.27 | 48.28±9.12 | <0.0001 |
| Hs-CRP, median (IQR), mg/L | 1.50 (0.68–3.53) | 1.00 (0.50–1.70) | 5.60 (3.90–8.90) | 0.90 (0.41–1.60) | 5.40 (3.90–8.50) | <0.0001 |
| Log(hs-CRP), mean±SD, mg/L | 0.40±1.34 | −0.23±1.03 | 1.87±0.66 | −0.26±1.00 | 1.87±0.68 | <0.0001 |
| BMI, mean±SD, kg/m2 | 26.20±3.50 | 25.89±3.43 | 26.83±3.82 | 26.01±3.25 | 26.79±3.56 | <0.0001 |
| Hypotensive medications (%) | 2,996 (19.1) | 1,186 (17.9) | 613 (21.0) | 819 (18.4) | 378 (22.6) | <0.0001 |
| Lipid-lowering medications (%) | 287 (1.74) | 117 (1.69) | 54 (1.71) | 78 (1.68) | 38 (2.10) | <0.0001 |
| Hypoglycemic medications (%) | 3,189 (20.8) | 1,359 (20.9) | 543 (19.0) | 953 (21.8) | 334 (20.5) | 0.0791 |
Notes: high eGFR: eGFR≥60 mL/min/1.73m2; low eGFR: eGFR<60 mL/min/1.73m2; high hs-CRP: hs-CRP≥3 mg/L; low hs-CRP: hs-CRP<3 mg/L. BMI is weight in kilograms divided by the height in meters squared.
Abbreviations: BMI, body mass index; hs-CRP, high-sensitivity C-reactive protein; DBP, diastolic blood pressure; FBG, fasting blood glucose; HDL-C, high-density lipoprotein cholesterol; HR, heart rate; IQR, interquartile range; LDL-C, low-density lipoprotein cholesterol; SBP, systolic blood pressure; SD, standard deviation; TC, total cholesterol; UA, urine acid.