. 2025 Jan 8;61(9):1894–1897. doi: 10.1039/d4cc06227b

Table 2. Catalytic ring contraction of an isoxazole to a chiral 2H-azirine^a.


Entry	Catalyst loading	T (°C)	t (h)	Yield^b	ee (%)
1	0.1 mol%	r.t.	0.25	99	72
2	1.0 mol%	−40	24	98 (95)^c	96
3	1.5 mol%	−50	40	95 (93)^c	97

Reaction conditions: Under N₂ atmosphere. A solution of Δ-(S_a,S_a)-Fe1-C₂ (0.1–1.5 mol%) in CH₂Cl₂ (0.5 mL) was added to substrate 6 (10 mg, 0.05 mmol) and stirred for the indicated time and temperature.

Yield was determined via¹H NMR analysis with 1,3,5-trimethoxybenzene as standard.

Isolated yield.

Table 2. Catalytic ring contraction of an isoxazole to a chiral 2H-azirinea.

Table 2. Catalytic ring contraction of an isoxazole to a chiral 2H-azirine^a.