Milk and dairy products – a scoping review for Nordic Nutrition Recommendations 2023

Kirsten Bjørklund Holven; Emily Sonestedt

doi:10.29219/fnr.v68.10486

. 2024 Dec 30;68:10.29219/fnr.v68.10486. doi: 10.29219/fnr.v68.10486

Milk and dairy products – a scoping review for Nordic Nutrition Recommendations 2023

Kirsten Bjørklund Holven ^1,^*, Emily Sonestedt ²

PMCID: PMC11708500 PMID: 39781268

Abstract

Milk and dairy products are major sources of protein, calcium, and other micronutrients. Milk and dairy products contribute with approximately half of the total intake of saturated fat in the Nordic and Baltic diets. Saturated fat is an important determinant of plasma total and low density lipoprotein (LDL)-cholesterol concentrations, and a causal relationship between high LDL-cholesterol and atherosclerotic cardiovascular disease has consistently been documented. The aim of this scoping review is to describe the evidence for the role of milk and dairy products for health-related outcomes as a basis for setting and updating food-based dietary guidelines. Two qualified systematic reviews were included (World Cancer Research Fund and a systematic review for the US Dietary Guidelines Advisory Committee 2020). In addition, systematic reviews published between January 2011 and January 2022 were considered, screened (555 records) and evaluated (159 records) for this review. The systematic reviews suggest that milk or dairy consumption is not associated with increased risk of cardiovascular disease and dyslipidaemia. Current evidence suggests an inverse association with some cardiometabolic risk factors, such as total and LDL-cholesterol, especially regarding fermented dairy products (i.e. yogurt and cheese). There was evidence of an association between intake of dairy products and reduced risk of colorectal cancer. Some studies reported an inverse association between intake of dairy and type 2 diabetes or markers of impaired glucose homeostasis, especially for low-fat dairy, yoghurt, and cheese. Most studies suggest that intake of milk or dairy is not associated with increased risk of cardiovascular risk and some suggestions of inverse association, especially with low-fat products and fermented dairy products, were found with respect to cardiovascular disease, type 2 diabetes, and colorectal cancer. Milk or dairy products are important dietary sources of calcium and iodine, and are fully compatible with a healthy dietary pattern.

Keywords: milk, dairy, cheese, yogurt, dietary recommendations

Popular scientific summary

Milk and dairy products are good sources of protein and essential amino acids, vitamin A, riboflavin, vitamin B12, calcium, and iodine.
Milk and dairy products are also major sources of saturated fatty acids in Nordic and Baltic diets.
Intake of dairy products is associated with lower risk of colorectal cancer.
Milk and dairy products in general are not associated with risk of cardiovascular disease, but may modestly reduce blood pressure.
Low-fat and fermented dairy products, such as yogurt and cheese, may be associated with lower serum cholesterol and risk of type 2 diabetes.
Health effects of milk and dairy products can differ based on both the nutrient composition and the structure of the products.

Dairy products are a heterogenous group of products. Milk from ruminants is both a food and a raw material for different dairy products such as cheese, cream, butter, and fermented milk (e.g. yogurt and sour milk). The fat content in milk varies from 0.1 g to around 4 g per 100 g, the protein content (whey and casein) is about 3.0–3.5 g per 100 g, and the carbohydrate content (disaccharide lactose consisting of glucose and galactose molecules) is about 4–5 g per 100 g. Whole milk and low-fat milk have the same proportions of fatty acids. Two-thirds of the fatty acids in milk consists of saturated fatty acids (SFA), mainly myristic (C14:0), palmitic (C16:0), and stearic (C18:0) acid. Milk also contains short-chain fatty acids, and small amounts of the odd-chain fatty acids C15:0 and C17:0 which are almost exclusively found in milk products. The main unsaturated fatty acid is oleic acid (C18:1). In addition, small amounts of trans-fatty acids are produced by bacteria in one of the cow’s stomachs (rumen), which makes milk the major source of trans-fats in countries where the industry-produced trans-fats have been reduced or eliminated. In fermented milk (i.e. yogurt and sour milk) selected bacteria are added and part of the lactose has been converted to lactic acid and other acids. Cheese contains essentially the same nutrients as milk except lactose. Cream is concentrated milk fat and therefore contains lower amounts of water-soluble vitamins, protein, and lactose.

Milk and dairy products are good sources of protein and essential amino acids, vitamin A, riboflavin, vitamin B₁₂, calcium, and iodine. Milk, yogurt, and cheese are the foods with the highest amounts of calcium. Whole-fat and low-fat milk contain about the same amounts of calcium (120 mg per 100 g), and cheese contains 750–940 mg calcium per 100 g. Around 60% of the calcium intake in the Nordic and Baltic diet is from milk products (1). Although milk products are generally good sources of micronutrients, they usually contain very little iron. In the Nordic countries, it is either mandatory or voluntarily with vitamin D fortification in milk (2). However, the products that are fortified and the amounts differ between countries. Compared to milk, the plant-based milks (e.g. from soy, oat, almond, rice, and pea) have a low content of many micronutrients and proteins. Currently, several plant-based milks fortified with calcium, vitamin B₁₂, and vitamin D are available.

Dairy products contribute approximately 50% of the saturated fat intake in the habitual diet in Nordic countries. A causal relationship between LDL-cholesterol and atherosclerotic cardiovascular disease (CVD) has consistently been documented (3, 4). Replacing SFA with polyunsaturated fat (PUFA) reduces risk of coronary heart disease (5–7) and effectively reduces plasma cholesterol levels (7, 8). Importantly, dairy products differ in their nutritional content as well as their physical structure. For example, cheese is high in saturated fat, but its composition is more like milk and yogurt than to that of butter. Because of differences in composition and structure, the health effects of various dairy foods may differ. For example, myristic and palmitic acids increase LDL-cholesterol concentrations more than lauric acid, while stearic acid has a neutral effect (9). The health effects are also likely more than the sum of the nutrients in dairy foods. In a systematic review for the Nordic Nutrition Recommendations (NNR) 2012, there was limited-suggestive evidence for total dairy consumption to be associated with decreased risk of type 2 diabetes, and suggestive evidence for total dairy consumption to be associated with increased risk of prostate cancer and decreased risk of colorectal cancer (10). However, since the health effects of different types of dairy products may differ, the aim of this scoping review is to describe the totality of evidence for the role of milk and dairy products for health-related outcomes as a basis for setting and updating food-based dietary guidelines in NNR 2023 (Box 1).

Box 1.

Background papers for Nordic Nutrition Recommendations 2023

This paper is one of many scoping reviews commissioned as part of the Nordic Nutrition Recommendations 2023 (NNR2023) project (11)
The papers are included in the extended NNR2023 report but, for transparency, these scoping reviews are also published in Food & Nutrition Research
The scoping reviews have been peer reviewed by independent experts in the research field according to the standard procedures of the journal
The scoping reviews have also been subjected to public consultations (see report to be published by the NNR2023 project)
The NNR2023 committee has served as the editorial board
While these papers are a main fundament, the NNR2023 committee has the sole responsibility for setting dietary reference values in the NNR2023 project

Methods

This scoping review follows the protocol developed within the NNR2023 project (11). The following qualified systematic reviews were identified by the NNR2023 Committee (12) and were included as source of evidence: The World Cancer Research Fund (WCRF) report (13) and one systematic review for the 2020 US Dietary Guidelines Advisory Committee (14). In addition, a literature search was performed in the PubMed database using the following search; (milk [MeSH Terms] OR dairy products [MeSH Terms] OR cheese [MeSH Terms]) AND (“2011”[Date – Publication] : “3000”[Date – Publication]) AND humans[Filter] AND (systematic review[Publication Type] OR meta-analysis[Publication Type]). Systematic reviews and meta-analysis published between January 2011 and January 2022 were considered, 555 publications were screened, and 159 abstracts were evaluated. The sources of evidence used in the review follow the eligibility criteria described previously (15). Finally, a separate search in PubMed was conducted in March 2022 on Mendelian randomization studies using the lactase persistence genotype as a proxy for long-term intake of lactose-containing dairy, using the following terms: (Mendelian randomization[Title/Abstract]) AND ((LCT[Title/Abstract]) OR (lactase[Title/Abstract]) OR (milk[Title/Abstract])). We included publications from meta-analyses or consortia. Only articles covering outcomes predefined for NNR2023 were selected. Out of 36 publications, 8 articles were included as sources of evidence (16–23) out of which 4 articles were also identified in the previous search.

Diet intake in Nordic and Baltic countries

Intake of milk and dairy products from the most recent national dietary surveys (year 2010–2020) is shown in Table 1. Intake of milk and dairy products ranges from 124 g/day among women in Lithuania to 480 g/day among men in Finland. Intake of cheese ranges from 15 g/day among women in Estonia to 46 g/day among men in Norway.

Table 1.

Consumption of milk and dairy products in the Nordic and Baltic countries.

Country, year (age group)	Gender	Milk and dairy products, g/day	Cheese, g/day
Denmark, 2011 (18–75 y)	Men (n = 1,464)	337 (274)	41 (35)
	Women (n = 1,552)	273 (197)	41 (31)
Finland, 2017 (18–74 y)	Men (n = 780)	480 (449–512)
	Women (n = 875)	394 (373–415)
Iceland, 2010 (18–80 y)	Men (n = 632)	353 (266)
	Women (n = 680)	251 (182)
Norway, 2010 (18–70 y)	Men (n = 862)	384 (354)	46 (44)
	Women (n = 925)	249 (237)	42 (38)
Sweden, 2010 (18–80 y)	Men (n = 792)	267 (231)	25 (28)
	Women (n = 1,005)	227 (171)	25 (28)
Estonia, 2014 (18–74 y)	Men (n = 907)	294 (220)	20 (22)
	Women (n = 1,806)	252 (223)	15 (23)
Latvia, 2020 (19–64 y)	Men (n = 470)	224 (222)
	Women (n = 541)	185 (156)
Lithuania, 2019 (19–75 y)	Men (n = 1,348)	140 (163)
	Women (n = 1562)	124 (131)

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Data are provided as mean and SD or 95% Confidence Interval (Finland). Data is retrieved from respective country’s most recent national dietary survey in adults.

Health outcomes

In the current review, we focused on the association between dairy intake and cardiovascular risk, type 2 diabetes, cancer, osteoporosis, hypertension, overweight/obesity and all-cause mortality. The main findings are described in more detail below.

Dairy and cardiovascular disease or risk factors

We identified 25 new systematic reviews published since 2010 regarding intake of dairy and CVD or cardiovascular risk factors, such as plasma total and LDL-cholesterol (10, 16, 24–43) and metabolic risk factors. Five of the systematic reviews studied the effect of dairy or specific dairy products on cardiovascular risk factor including total and LDL cholesterol. Two systematic reviews including only randomized studies found either no significant effect of dairy products on neither LDL or high density lipoprotein (HDL) cholesterol (24), or that consumption of dairy can either increase or decrease lipids dependent on the specific type of dairy product (28). One systematic review investigating only the effect of cheese found that cheese reduced total, LDL and HDL cholesterol compared to butter (25). The systematic reviews overall conclude that milk or dairy consumption is not associated with increased risk of CVD. Most of the meta-analyses investigating effects on CVD found neutral or favorable association (27, 36, 37) with intake of dairy products or specific dairy products; yogurt (44), cheese (25, 31), and fermented dairy (40). Few studies have directly compared the effect of low- versus high-fat dairy products; however, one meta-analysis investigated the consumption of full-fat or low-fat dairy products and found no association between either type of dairy and all-cause mortality and CVD incidence (45), whereas one systematic review showed that intake of high-fat milk compared to low-fat milk was associated with increased CVD risk (31).

Dairy and cancer

We identified 31 new systematic reviews (17, 44–74). WCRF reported that there was strong evidence that intake of dairy products reduces the risk of colorectal cancer (75). There was limited evidence suggesting that dairy products decrease the risk of premenopausal breast cancer and limited evidence for a positive association between high intake of dairy products and risk of prostate cancer (75).

Dairy and risk of type 2 diabetes, overweight, and obesity

We identified eight systematic reviews regarding the intake of dairy and diabetes (76–83). An inverse association between intake of dairy and type 2 diabetes or risk factors for type 2 diabetes (e.g. Homeostatic Model Assessment for Insulin Resistance; HOMA-IR) was suggested for most studies, specifically for low-fat dairy, yogurt, and cheese. Regarding intake of dairy and overweight/obesity, we identified eight systematic reviews (84–91). However, the evidence is insufficient and inconsistent regarding the association between intake of dairy foods and risk of obesity or body weight gain. The 2020 US Dietary Guidelines Advisory Committee concluded that there is limited evidence suggesting that high milk consumption is not associated with adiposity in neither children nor adults (92).

Dairy and bone health

We identified eight systematic reviews and/or meta-analyses published regarding the intake of dairy and bone health or markers of bone health (18, 93–99). Evidence for beneficial effects for adults was inconsistent and limited, but the overall evidence does not support a link between dairy consumption and fractures. There is some evidence from intervention studies that milk intake in childhood and adolescent age results in faster linear growth and a positive effect on bone health.

Dairy and other health markers

We identified six new systematic reviews and/or meta-analyses published regarding the intake of dairy and hypertension or blood pressure (19, 100–104). No evidence for a detrimental effect related to intake of dairy products was seen. A modest, beneficial effect on blood pressure was reported in most studies. We identified 10 new systematic reviews and/or meta-analyses study published regarding the intake of dairy and all-cause mortality (35, 37, 105–112). Most of the studies found no association between total dairy intake and all-cause mortality.

Mendelian randomization studies using genetic variation as a proxy for long-term milk intake

The Mendelian randomization analyses provide support for a causal association between lactose-containing dairy (i.e. milk) intake and higher BMI, lower LDL and HDL cholesterol (16), higher waist circumference, lean body mass (20), and higher insulin (23). Mendelian randomization analyses suggest a reduced risk of colorectal cancer with high milk intake, but there is no or limited evidence that milk consumption affects the risk of bladder, breast, and prostate cancer (17). There is no support that genetically predicted adult milk intake is associated with systolic blood pressure (19), hip fractures (18), bone mineral density, ischemic heart disease, or type 2 diabetes (21, 23).

Mechanisms

Cardiovascular disease

Although milk and dairy products are major sources of SFA, which increases plasma total, LDL- and HDL cholesterol levels compared with carbohydrates, dairy consumption has not been shown consistently to increase total and LDL cholesterol. However, replacing full-fat dairy products with low-fat products is associated with a dietary pattern that is more beneficial for cardiovascular health (11). Dairy products consist of very heterogenous food groups with different composition. While some dairy types, for example, milk, yogurt, cheese, and fermented dairy foods, are associated with a neutral or favorably lipid profile, butter and full-fat milk are associated with an unfavorable lipid profile. In addition to the long-chain SFA, they also contain medium- and odd-chain SFA, trans-fatty acids, unsaturated fatty acids, branched-chained amino acids, other nutrients (e.g. calcium, iodine, vitamin K), and bioactive components such as bioactive peptides, which all are potentially mediating different effects. Moreover, dairy foods also have different other characteristics with some dairy products being fermented, being differently processed, and the dairy matrix is different. All these differences can modulate their bioavailability and subsequently their metabolic effect. Calcium and bioactive peptides have been suggested to mediate beneficial effects, for example, on blood pressure and blood cholesterol, while some dairy products also have been suggested to influence markers of inflammation (113, 114). A recent review concluded that milk or dairy products did not show any proinflammatory effect in healthy subjects or individuals with metabolic abnormalities (114). In addition, other beneficial mechanisms have been suggested, such as reduced lipid absorption (by different food matrix) and microbial fermentation producing short chain fatty acids such as butyrate (45). Therefore, because dairy foods being such a heterogenous group of products containing numerous different nutrients influenced by their specific matrix, it is not easy to draw a firm conclusion on their health effects. More studies are needed to determine the effect of specific dairy products on CVD risk.

Cancer

The mechanisms involved in the possible inverse association between dairy products and colorectal cancer are at present unclear. The high calcium content of dairy products has been attributed for the protective effect (13). Fatty acids and bile acids in the colon may play a role in the initial phase of the carcinogenesis, and calcium could protect by sequestration of secondary bile acids. Conjugated linoleic acid present in dairy foods has also been suggested to be protective, for example, by inhibiting cell proliferation, decreasing inflammatory mediators, and stimulating the immune system (48).

Diabetes, overweight, and obesity

Several mechanisms have been put forward regarding the potential beneficial effect of dairy products on type 2 diabetes risk. Milk proteins, such as whey, may have insulinotropic activity, and calcium is essential for insulin secretion by β-cells. Dairy foods contain short- and medium-chain fatty acids that has been suggested to possess a range of biological activities including induction of hormones influencing insulin sensitivity and impact the microbiota, regulate energy metabolism, improve β-cell function, and reduce inflammation (115). Consumption of dairy may facilitate maintaining body weight and fat loss because of the content of calcium, protein (casein and whey), and other bioactive compounds in dairy foods that may favorably affect energy balance. Calcium interacts with fatty acids in the intestine and may thereby reduce absorption of fat. Full-fat dairy products, such as butter, (sour) cream, and full-fat cheese, are energy-dense foods, and high intake of these may lead to energy surplus. Several dairy products contain probiotic bacteria that interact with the normal bacteria flora. Some fermented dairy products seem to have a more beneficial effect on circulating inflammatory markers than non-fermented dairy products (116).

Bone health

Osteoporosis is defined as reduced bone mineral density and increased bone fragility, and is a major public health problem. In the Nordic countries, milk and dairy products are important sources of nutrients associated with bone health, first and foremost calcium and vitamin D. Calcium is an important component of the skeleton, and vitamin D is involved in absorption of calcium from the intestine and the regulation of calcium metabolism, leading to increased bone mineralization (117).

Food-based dietary guidelines

Summary

Dairy products are a heterogenous group of products including, for example, milk, cheese, and yogurt. New evidence suggests that effects on health outcomes mediated by dairy products differ and extend beyond their individual nutritional composition. Because dairy products contain animal fat, with a large proportion being saturated fat, high consumption of high-fat dairy products can lead to high intake of saturated fat. This may contribute to an increased risk of CVD. However, milk or dairy consumption has not been associated with increased risk of CVD. Current evidence suggests inverse associations with cardiometabolic risk, especially regarding fermented dairy products (i.e. yogurt and cheese). In addition, an inverse association with intake of dairy and type 2 diabetes has been reported, specifically for low-fat dairy, yogurt, and cheese. However, replacing full-fat dairy products with low-fat products is associated with a dietary pattern more beneficial for cardiovascular health. There is evidence for an association between intake of dairy products and reduced risk of colorectal cancer, and some evidence for a protective effect of dairy food on risk of obesity.

Dairy products (especially milk, yogurt, and cheese) are important sources of calcium, protein, iodine, and other important nutrients. To satisfy the need for calcium, 6 deciliters of milk alone or 2–5 dL a day of milk, depending on what other foods are included in the diet, is sufficient. The amount of fat varies substantially between dairy products. To avoid consuming too much saturated fat, low-fat milk, and cheese should preferably be chosen. Dairy products that are not a major source of essential nutrients nor associated with health effects, that is, cream and butter, should be limited.

Rather than assuming that two dairy foods with similar nutritional content have the same health effects, the health effects of specific dairy foods should be considered. Thus, the physiological effects of a dairy food cannot necessarily be predicted solely based on its nutritional content or fat composition. The evidence suggests that the health effects of different dairy products vary, even for dairy foods with high fat content (i.e. butter and cheese), and the food matrix and content of bioactive compounds need to be considered to clarify the potential beneficial effect of dairy products.

Data gaps for future research

Several new systematic reviews and meta-analyses have been published since NNR 2012, and a few of these have looked at specific dairy products (e.g. cheese and yogurt). However, there are still too few studies to draw firm conclusions. Current evidence suggests no association between milk and dairy intake and CVD, and the consequence of shifting from low- to more full-fat dairy could be explored further.

Different dairy products may possess different effects depending on fermentation degree, matrix nutrient composition, and bacteria strain used; therefore, more studies on the effect of the different dairy products are needed. Moreover, little focus has been on systematically comparing the effect of low- versus full-fat dairy because most studies compare different dairy products to another or another food source containing saturated fat. In addition, there is a need to compare plant-based dairy alternatives to cow’s milk on health outcomes.

Finally, there is also a need for more studies using objective biomarkers of dairy consumption, including circulating biomarkers or genetic markers.

Conflict of interest and funding

The authors have not received any funding or benefits from industry or elsewhere to conduct this study, and report no conflicts of interests. The authors received a small reimbursement from the Norwegian Directorate of Health for work linked to this article.

References

1.Totland TH, Melnæs BK, Lundberg-Hallén N, Helland-Kigen KM, Lund-Blix NA, Myhre JB, et al. Norkost 3. En landsomfattende kostholdsundersøkelse blant menn og kvinner i Norge i alderen 18–70 år, 2010–11. no. 3. Oslo: Helsedirektoratet; 2012. [Google Scholar]
2.Itkonen ST, Andersen R, Björk AK, et al. Vitamin D status and current policies to achieve adequate vitamin D intake in the Nordic countries. Scand J Public Health 2021; 49: 616–27. doi: 10.1177/1403494819896878 [DOI] [PubMed] [Google Scholar]
3.Borén J, Chapman MJ, Krauss RM, et al. Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel. Eur Heart J 2020; 41: 2313–30. doi: 10.1093/eurheartj/ehz962 [DOI] [PMC free article] [PubMed] [Google Scholar]
4.Ference BA, Ginsberg HN, Graham I, et al. Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel. Eur Heart J 2017; 38: 2459–72. doi: 10.1093/eurheartj/ehx144 [DOI] [PMC free article] [PubMed] [Google Scholar]
5.Jakobsen MU, O’Reilly EJ, Heitmann BL, et al. Major types of dietary fat and risk of coronary heart disease: a pooled analysis of 11 cohort studies. Am J Clin Nutr 2009; 89: 1425–32. doi: 10.3945/ajcn.2008.27124 [DOI] [PMC free article] [PubMed] [Google Scholar]
6.Mozaffarian D, Micha R, Wallace S. Effects on coronary heart disease of increasing polyunsaturated fat in place of saturated fat: a systematic review and meta-analysis of randomized controlled trials. PLoS Med 2010; 7: e1000252. doi: 10.1371/journal.pmed.1000252 [DOI] [PMC free article] [PubMed] [Google Scholar]
7.Sacks FM, Lichtenstein AH, Wu JHY, et al. Dietary fats and cardiovascular disease: a presidential advisory from the American Heart Association. Circulation 2017; 136: e1–e23. 10.1161/CIR.0000000000000510 [DOI] [PubMed] [Google Scholar]
8.Hooper L, Martin N, Jimoh OF, et al. Reduction in saturated fat intake for cardiovascular disease. Cochrane Database Syst Rev 2020; 5: CD011737. doi: 10.1002/14651858.CD011737.pub2 [DOI] [PMC free article] [PubMed] [Google Scholar]
9.Mensink RP, Temme EH, Hornstra G. Dietary saturated and trans fatty acids and lipoprotein metabolism. Ann Med 1994; 26: 461–4. doi: 10.3109/07853899409148369 [DOI] [PubMed] [Google Scholar]
10.Åkesson A, Andersen LF, Kristjansdottir AG, et al. Health effects associated with foods characteristic of the Nordic diet: a systematic literature review. Food Nutr Res 2013; 57: 22790. doi: 10.3402/fnr.v57i0.22790 [DOI] [PMC free article] [PubMed] [Google Scholar]
11.Blomhoff R, Andersen R, Arnesen EK, et al. Nordic Nutrition Recommendations 2023. Copenhagen: Nordic Council of Ministers; 2023. [Google Scholar]
12.Høyer A, Christensen JJ, Arnesen EK, et al. The Nordic Nutrition Recommendations 2022 – prioritisation of topics for de novo systematic reviews. Food Nutr Res 2021; 65: 7828. doi: 10.29219/fnr.v65.7828 [DOI] [PMC free article] [PubMed] [Google Scholar]
13.World Cancer Research/American Institute for Cancer Research . Continuous Update Project Expert Report 2018. Meat, fish and dairy products and the risk of cancer. 2018. [Google Scholar]
14.Mayer-Davis E, Leidy H, Mattes R, et al. Beverage consumption and growth, size, body composition, and risk of overweight and obesity: a systematic review. Alexandria, VA: USDA Nutrition Evidence Systematic Review; 2020. [PubMed] [Google Scholar]
15.Christensen JJ, Arnesen EK, Andersen R, et al. The Nordic Nutrition Recommendations 2022 – principles and methodologies. Food Nutr Res 2020; 64: 4402. doi: 10.29219/fnr.v64.4402 [DOI] [PMC free article] [PubMed] [Google Scholar]
16.Vimaleswaran KS, Zhou A, Cavadino A, et al. Evidence for a causal association between milk intake and cardiometabolic disease outcomes using a two-sample Mendelian Randomization analysis in up to 1,904,220 individuals. Int J Obes 2021; 45: 1751–62. doi: 10.1038/s41366-021-00841-2 [DOI] [PMC free article] [PubMed] [Google Scholar]
17.Larsson SC, Mason AM, Kar S, et al. Genetically proxied milk consumption and risk of colorectal, bladder, breast, and prostate cancer: a two-sample Mendelian randomization study. BMC Med 2020; 18: 370. [DOI] [PMC free article] [PubMed] [Google Scholar]
18.Bergholdt HKM, Larsen MK, Varbo A, et al. Lactase persistence, milk intake, hip fracture and bone mineral density: a study of 97 811 Danish individuals and a meta-analysis. J Intern Med 2018; 284: 254–69. doi: 10.1111/joim.12753 [DOI] [PubMed] [Google Scholar]
19.Ding M, Huang T, Bergholdt HK, et al. Dairy consumption, systolic blood pressure, and risk of hypertension: Mendelian randomization study. BMJ (Clinical research ed) 2017; 356: j1000. doi: 10.1136/bmj.j1000 [DOI] [PMC free article] [PubMed] [Google Scholar]
20.Huang T, Sun D, Heianza Y, et al. Dairy intake and body composition and cardiometabolic traits among adults: Mendelian randomization analysis of 182041 individuals from 18 studies. Clin Chem 2019; 65: 751–60. doi: 10.1373/clinchem.2018.300335 [DOI] [PMC free article] [PubMed] [Google Scholar]
21.Vissers LET, Sluijs I, van der Schouw YT, et al. Dairy product intake and risk of type 2 diabetes in EPIC-InterAct: a Mendelian randomization study. Diabetes Care 2019; 42: 568–75. doi: 10.2337/dc18-2034 [DOI] [PMC free article] [PubMed] [Google Scholar]
22.Mendelian Randomization of Dairy Consumption Working Group Dairy consumption and body mass index among adults: Mendelian randomization analysis of 184802 individuals from 25 studies. Clin Chem 2018; 64: 183–91. doi: 10.1373/clinchem.2017.280701 [DOI] [PMC free article] [PubMed] [Google Scholar]
23.Yang Q, Lin SL, Au Yeung SL, et al. Genetically predicted milk consumption and bone health, ischemic heart disease and type 2 diabetes: a Mendelian randomization study. Eur J Clin Nutr 2017; 71: 1008–12. doi: 10.1038/ejcn.2017.8 [DOI] [PubMed] [Google Scholar]
24.Benatar JR, Sidhu K, Stewart RA. Effects of high and low fat dairy food on cardio-metabolic risk factors: a meta-analysis of randomized studies. PLoS One 2013; 8: e76480. doi: 10.1371/journal.pone.0076480 [DOI] [PMC free article] [PubMed] [Google Scholar]
25.Chen GC, Wang Y, Tong X, et al. Cheese consumption and risk of cardiovascular disease: a meta-analysis of prospective studies. Eur J Nutr 2017; 56: 2565–75. doi: 10.1007/s00394-016-1292-z [DOI] [PubMed] [Google Scholar]
26.Diez-Fernández A, Álvarez-Bueno C, Martínez-Vizcaíno V, et al. Total dairy, cheese and milk intake and arterial stiffness: a systematic review and meta-analysis of cross-sectional studies. Nutrients 2019; 11(4): 741. doi: 10.3390/nu11040741 [DOI] [PMC free article] [PubMed] [Google Scholar]
27.Drouin-Chartier JP, Brassard D, Tessier-Grenier M, et al. Systematic review of the association between dairy product consumption and risk of cardiovascular-related clinical outcomes. Adv Nutr 2016; 7: 1026–40. doi: 10.3945/an.115.011403 [DOI] [PMC free article] [PubMed] [Google Scholar]
28.Duarte C, Boccardi V, Amaro Andrade P, et al. Dairy versus other saturated fats source and cardiometabolic risk markers: systematic review of randomized controlled trials. Crit Rev Food Sci Nutr 2021; 61: 450–61. doi: 10.1080/10408398.2020.1736509 [DOI] [PubMed] [Google Scholar]
29.Dumas AA, Lapointe A, Dugrenier M, et al. A systematic review of the effect of yogurt consumption on chronic diseases risk markers in adults. Eur J Nutr 2017; 56: 1375–92. doi: 10.1007/s00394-016-1341-7 [DOI] [PubMed] [Google Scholar]
30.Hu D, Huang J, Wang Y, et al. Dairy foods and risk of stroke: a meta-analysis of prospective cohort studies. Nutr metabolCardiovasc Dis 2014; 24: 460–9. doi: 10.1016/j.numecd.2013.12.006 [DOI] [PubMed] [Google Scholar]
31.Jakobsen MU, Trolle E, Outzen M, et al. Intake of dairy products and associations with major atherosclerotic cardiovascular diseases: a systematic review and meta-analysis of cohort studies. Sci Rep 2021; 11: 1303. doi: 10.1038/s41598-020-79708-x [DOI] [PMC free article] [PubMed] [Google Scholar]
32.Kim Y, Je Y. Dairy consumption and risk of metabolic syndrome: a meta-analysis. Diabet Med 2016; 33: 428–40. doi: 10.1111/dme.12970 [DOI] [PubMed] [Google Scholar]
33.Lee M, Lee H, Kim J. Dairy food consumption is associated with a lower risk of the metabolic syndrome and its components: a systematic review and meta-analysis. Br J Nutr 2018; 120: 373–84. doi: 10.1017/S0007114518001460 [DOI] [PubMed] [Google Scholar]
34.Mena-Sánchez G, Becerra-Tomás N, Babio N, et al. Dairy product consumption in the prevention of metabolic syndrome: a systematic review and meta-analysis of prospective cohort studies. Adv Nutr 2019; 10: S144–53. doi: 10.1093/advances/nmy083 [DOI] [PMC free article] [PubMed] [Google Scholar]
35.Smith CE, Coltell O, Sorlí JV, et al. Associations of the MCM6-rs3754686 proxy for milk intake in Mediterranean and American populations with cardiovascular biomarkers, disease and mortality: Mendelian randomization. Sci Rep 2016; 6: 33188. doi: 10.1038/srep33188 [DOI] [PMC free article] [PubMed] [Google Scholar]
36.Soedamah-Muthu SS, de Goede J. Dairy consumption and cardiometabolic diseases: systematic review and updated meta-analyses of prospective cohort studies. Curr Nutr Rep 2018; 7: 171–82. doi: 10.1007/s13668-018-0253-y [DOI] [PMC free article] [PubMed] [Google Scholar]
37.Soedamah-Muthu SS, Ding EL, Al-Delaimy WK, et al. Milk and dairy consumption and incidence of cardiovascular diseases and all-cause mortality: dose-response meta-analysis of prospective cohort studies. Am J Clin Nutr 2011; 93: 158–71. doi: 10.3945/ajcn.2010.29866 [DOI] [PMC free article] [PubMed] [Google Scholar]
38.Soto-Méndez MJ, Rangel-Huerta OD, Ruiz-López MD, et al. Role of functional fortified dairy products in cardiometabolic health: a systematic review and meta-analyses of randomized clinical trials. Adv Nutr 2019; 10: S251–71. doi: 10.1093/advances/nmz001 [DOI] [PMC free article] [PubMed] [Google Scholar]
39.Wu L, Sun D. Consumption of Yogurt and the incident risk of cardiovascular disease: a meta-analysis of nine cohort studies. Nutrients 2017; 9(3): 315. doi: 10.3390/nu9030315 [DOI] [PMC free article] [PubMed] [Google Scholar]
40.Zhang K, Chen X, Zhang L, et al. Fermented dairy foods intake and risk of cardiovascular diseases: a meta-analysis of cohort studies. Crit Rev Food Sci Nutr 2020; 60: 1189–94. doi: 10.1080/10408398.2018.1564019 [DOI] [PubMed] [Google Scholar]
41.Jin S, Je Y. Dairy consumption and risk of metabolic syndrome: results from Korean population and meta-analysis. Nutrients 2021; 13(5): 1574. doi: 10.3390/nu13051574 [DOI] [PMC free article] [PubMed] [Google Scholar]
42.Trieu K, Bhat S, Dai Z, et al. Biomarkers of dairy fat intake, incident cardiovascular disease, and all-cause mortality: a cohort study, systematic review, and meta-analysis. PLoS Med 2021; 18: e1003763. doi: 10.1371/journal.pmed.1003763 [DOI] [PMC free article] [PubMed] [Google Scholar]
43.Ziaei R, Ghavami A, Khalesi S, et al. The effect of probiotic fermented milk products on blood lipid concentrations: a systematic review and meta-analysis of randomized controlled trials. Nutr Metabol Cardiovasc Dis 2021; 31: 997–1015. doi: 10.1016/j.numecd.2020.12.023 [DOI] [PubMed] [Google Scholar]
44.Wu Y, Huang R, Wang M, et al. Dairy foods, calcium, and risk of breast cancer overall and for subtypes defined by estrogen receptor status: a pooled analysis of 21 cohort studies. Am J Clin Nutr 2021; 114: 450–61. doi: 10.1093/ajcn/nqab097 [DOI] [PMC free article] [PubMed] [Google Scholar]
45.Guo J, Astrup A, Lovegrove JA, et al. Milk and dairy consumption and risk of cardiovascular diseases and all-cause mortality: dose-response meta-analysis of prospective cohort studies. Eur J Epidemiol 2017; 32: 269–87. doi: 10.1007/s10654-017-0243-1 [DOI] [PMC free article] [PubMed] [Google Scholar]
46.Aune D, Lau R, Chan DSM, et al. Dairy products and colorectal cancer risk: a systematic review and meta-analysis of cohort studies. Ann Oncol 2012; 23: 37–45. doi: 10.1093/annonc/mdr269 [DOI] [PubMed] [Google Scholar]
47.Aune D, Navarro Rosenblatt DA, Chan DS, et al. Dairy products, calcium, and prostate cancer risk: a systematic review and meta-analysis of cohort studies. Am J Clin Nutr 2015; 101: 87–117. doi: 10.3945/ajcn.113.067157 [DOI] [PubMed] [Google Scholar]
48.Barrubés L, Babio N, Becerra-Tomás N, et al. Association between dairy product consumption and colorectal cancer risk in adults: a systematic review and meta-analysis of epidemiologic studies. Adv Nutr 2018; 10: S190–211. doi: 10.1093/advances/nmy114 [DOI] [PMC free article] [PubMed] [Google Scholar]
49.Bermejo LM, López-Plaza B, Santurino C, et al. Milk and dairy product consumption and bladder cancer risk: a systematic review and meta-analysis of observational studies. Adv Nutr 2019; 10: S224–38. doi: 10.1093/advances/nmy119 [DOI] [PMC free article] [PubMed] [Google Scholar]
50.Chen L, Li M, Li H. Milk and yogurt intake and breast cancer risk: a meta-analysis. Medicine (Baltimore) 2019; 98: e14900. doi: 10.1097/MD.0000000000014900 [DOI] [PMC free article] [PubMed] [Google Scholar]
51.Dong JY, Zhang L, He K, et al. Dairy consumption and risk of breast cancer: a meta-analysis of prospective cohort studies. Breast Cancer Res Treat 2011; 127: 23–31. doi: 10.1007/s10549-011-1467-5 [DOI] [PubMed] [Google Scholar]
52.Genkinger JM, Wang M, Li R, et al. Dairy products and pancreatic cancer risk: a pooled analysis of 14 cohort studies. Ann Oncol 2014; 25: 1106–15. doi: 10.1093/annonc/mdu019 [DOI] [PMC free article] [PubMed] [Google Scholar]
53.Guo Y, Shan Z, Ren H, et al. Dairy consumption and gastric cancer risk: a meta-analysis of epidemiological studies. Nutr Cancer 2015; 67: 555–68. doi: 10.1080/01635581.2015.1019634 [DOI] [PubMed] [Google Scholar]
54.Jeyaraman MM, Abou-Setta AM, Grant L, et al. Dairy product consumption and development of cancer: an overview of reviews. BMJ Open 2019; 9: e023625. doi: 10.1136/bmjopen-2018-023625 [DOI] [PMC free article] [PubMed] [Google Scholar]
55.Li BL, Jiang GX, Xue Q, et al. Dairy consumption and risk of esophageal squamous cell carcinoma: a meta-analysis of observational studies. Asia Pac J Clin Oncol 2016; 12: e269–79. doi: 10.1111/ajco.12183 [DOI] [PubMed] [Google Scholar]
56.Li F, An SL, Zhou Y, et al. Milk and dairy consumption and risk of bladder cancer: a meta-analysis. Urology 2011; 78: 1298–305. doi: 10.1016/j.urology.2011.09.002 [DOI] [PubMed] [Google Scholar]
57.Li X, Zhao J, Li P, et al. Dairy products intake and endometrial cancer risk: a meta-analysis of observational studies. Nutrients 2017; 10(1): 25. doi: 10.3390/nu10010025 [DOI] [PMC free article] [PubMed] [Google Scholar]
58.Lu W, Chen H, Niu Y, et al. Dairy products intake and cancer mortality risk: a meta-analysis of 11 population-based cohort studies. Nutr J 2016; 15: 91. doi: 10.1186/s12937-016-0210-9 [DOI] [PMC free article] [PubMed] [Google Scholar]
59.Mao QQ, Dai Y, Lin YW, et al. Milk consumption and bladder cancer risk: a meta-analysis of published epidemiological studies. Nutr Cancer 2011; 63: 1263–71. doi: 10.1080/01635581.2011.614716 [DOI] [PubMed] [Google Scholar]
60.Ralston RA, Truby H, Palermo CE, et al. Colorectal cancer and nonfermented milk, solid cheese, and fermented milk consumption: a systematic review and meta-analysis of prospective studies. Crit Rev Food Sci Nutr 2014; 54: 1167–79. doi: 10.1080/10408398.2011.629353 [DOI] [PubMed] [Google Scholar]
61.Sergentanis TN, Ntanasis-Stathopoulos I, Tzanninis IG, et al. Meat, fish, dairy products and risk of hematological malignancies in adults – a systematic review and meta-analysis of prospective studies. Leuk Lymphoma 2019; 60: 1978–90. doi: 10.1080/10428194.2018.1563693 [DOI] [PubMed] [Google Scholar]
62.Signal V, Huang S, Sarfati D, et al. Dairy consumption and risk of testicular cancer: a systematic review. Nutr Cancer 2018; 70: 710–36. doi: 10.1080/01635581.2018.1470655 [DOI] [PMC free article] [PubMed] [Google Scholar]
63.Tian SB, Yu JC, Kang WM, et al. Association between dairy intake and gastric cancer: a meta-analysis of observational studies. PLoS One 2014; 9: e101728. doi: 10.1371/journal.pone.0101728 [DOI] [PMC free article] [PubMed] [Google Scholar]
64.Wang J, Li X, Zhang D. Dairy product consumption and risk of non-Hodgkin lymphoma: a meta-analysis. Nutrients 2016; 8: 120. doi: 10.3390/nu8030120 [DOI] [PMC free article] [PubMed] [Google Scholar]
65.Wu J, Yu Y, Huang L, et al. Dairy product consumption and bladder cancer risk: a meta-analysis. Nutr Cancer 2020; 72: 377–85. doi: 10.1080/01635581.2019.1637909 [DOI] [PubMed] [Google Scholar]
66.Wu J, Zeng R, Huang J, et al. Dietary protein sources and incidence of breast cancer: a dose-response meta-analysis of prospective studies. Nutrients 2016; 8(11): 730. doi: 10.3390/nu8110730 [DOI] [PMC free article] [PubMed] [Google Scholar]
67.Yang Y, Wang X, Yao Q, et al. Dairy product, calcium intake and lung cancer risk: a systematic review with meta-analysis. Sci Rep 2016; 6: 20624. doi: 10.1038/srep20624 [DOI] [PMC free article] [PubMed] [Google Scholar]
68.Yuan J, Li W, Sun W, et al. Milk and dairy products consumption and the risk of oral or oropharyngeal cancer: a meta-analysis. Biosci Rep 2019; 39: BSR20193526. doi: 10.1042/BSR20193526 [DOI] [PMC free article] [PubMed] [Google Scholar]
69.Zhang K, Dai H, Liang W, et al. Fermented dairy foods intake and risk of cancer. Int J Cancer 2019; 144: 2099–108. doi: 10.1002/ijc.31959 [DOI] [PubMed] [Google Scholar]
70.Acham M, Wesselius A, van Osch FHM, et al. Intake of milk and other dairy products and the risk of bladder cancer: a pooled analysis of 13 cohort studies. Eur J Clin Nutr 2020; 74: 28–35. doi: 10.1038/s41430-019-0453-6 [DOI] [PubMed] [Google Scholar]
71.Chapelle N, Martel M, Toes-Zoutendijk E, et al. Recent advances in clinical practice: colorectal cancer chemoprevention in the average-risk population. Gut 2020; 69: 2244–55. doi: 10.1136/gutjnl-2020-320990 [DOI] [PMC free article] [PubMed] [Google Scholar]
72.He Y, Tao Q, Zhou F, et al. The relationship between dairy products intake and breast cancer incidence: a meta-analysis of observational studies. BMC Cancer 2021; 21: 1109. doi: 10.1186/s12885-021-08854-w [DOI] [PMC free article] [PubMed] [Google Scholar]
73.Jin S, Kim Y, Je Y. Dairy consumption and risks of colorectal cancer incidence and mortality: a meta-analysis of prospective cohort studies. Cancer Epidemiol Biomarkers Prev 2020; 29: 2309–22. doi: 10.1158/1055-9965.EPI-20-0127 [DOI] [PubMed] [Google Scholar]
74.Liao MQ, Gao XP, Yu XX, et al. Effects of dairy products, calcium and vitamin D on ovarian cancer risk: a meta-analysis of twenty-nine epidemiological studies. Br J Nutr 2020; 124: 1001–12. doi: 10.1017/S0007114520001075 [DOI] [PubMed] [Google Scholar]
75.Wild CP, Weiderpass E, Stewart BW, eds. World cancer report: cancer research for cancer prevention. Lyon, France: International Agency for Research on Cancer; 2020. [PubMed] [Google Scholar]
76.Aune D, Norat T, Romundstad P, et al. Dairy products and the risk of type 2 diabetes: a systematic review and dose-response meta-analysis of cohort studies. Am J Clin Nutr 2013; 98: 1066–83. doi: 10.3945/ajcn.113.059030 [DOI] [PubMed] [Google Scholar]
77.Chen M, Sun Q, Giovannucci E, et al. Dairy consumption and risk of type 2 diabetes: 3 cohorts of US adults and an updated meta-analysis. BMC Med 2014; 12: 215. doi: 10.1186/s12916-014-0215-1 [DOI] [PMC free article] [PubMed] [Google Scholar]
78.Gao D, Ning N, Wang C, et al. Dairy products consumption and risk of type 2 diabetes: systematic review and dose-response meta-analysis. PLoS One 2013; 8: e73965. doi: 10.1371/journal.pone.0073965 [DOI] [PMC free article] [PubMed] [Google Scholar]
79.O’Connor S, Turcotte AF, Gagnon C, et al. Increased dairy product intake modifies plasma glucose concentrations and glycated hemoglobin: a systematic review and meta-analysis of randomized controlled trials. Adv Nutr 2019; 10: 262–79. doi: 10.1093/advances/nmy074 [DOI] [PMC free article] [PubMed] [Google Scholar]
80.Sochol KM, Johns TS, Buttar RS, et al. The effects of dairy intake on insulin resistance: a systematic review and meta-analysis of randomized clinical trials. Nutrients 2019; 11: 2237. doi: 10.3390/nu11092237 [DOI] [PMC free article] [PubMed] [Google Scholar]
81.Tong X, Dong JY, Wu ZW, et al. Dairy consumption and risk of type 2 diabetes mellitus: a meta-analysis of cohort studies. Eur J Clin Nutr 2011; 65: 1027–31. doi: 10.1038/ejcn.2011.62 [DOI] [PubMed] [Google Scholar]
82.Turner KM, Keogh JB, Clifton PM. Dairy consumption and insulin sensitivity: a systematic review of short- and long-term intervention studies. Nutr MetabolCardiovasc Diseases 2015; 25: 3–8. doi: 10.1016/j.numecd.2014.07.013 [DOI] [PubMed] [Google Scholar]
83.Salari A, Ghodrat S, Gheflati A, et al. Effect of kefir beverage consumption on glycemic control: a systematic review and meta-analysis of randomized controlled clinical trials. Complement Ther Clin Pract 2021; 44: 101443. doi: 10.1016/j.ctcp.2021.101443 [DOI] [PubMed] [Google Scholar]
84.Eales J, Lenoir-Wijnkoop I, King S, et al. Is consuming yoghurt associated with weight management outcomes? Results from a systematic review. Int J Obes (Lond) 2016; 40: 731–46. doi: 10.1038/ijo.2015.202 [DOI] [PMC free article] [PubMed] [Google Scholar]
85.Hartwig FP, Horta BL, Smith GD, et al. Association of lactase persistence genotype with milk consumption, obesity and blood pressure: a Mendelian randomization study in the 1982 Pelotas (Brazil) Birth Cohort, with a systematic review and meta-analysis. Int J Epidemiol 2016; 45: 1573–87. doi: 10.1093/ije/dyw074 [DOI] [PMC free article] [PubMed] [Google Scholar]
86.Lu L, Xun P, Wan Y, et al. Long-term association between dairy consumption and risk of childhood obesity: a systematic review and meta-analysis of prospective cohort studies. Eur J Clin Nutr 2016; 70: 414–23. doi: 10.1038/ejcn.2015.226 [DOI] [PubMed] [Google Scholar]
87.Sayon-Orea C, Martínez-González MA, Ruiz-Canela M, et al. Associations between yogurt consumption and weight gain and risk of obesity and metabolic syndrome: a systematic review. Adv Nutr 2017; 8: 146s–54s. doi: 10.3945/an.115.011536 [DOI] [PMC free article] [PubMed] [Google Scholar]
88.Schwingshackl L, Hoffmann G, Schwedhelm C, et al. Consumption of dairy products in relation to changes in anthropometric variables in adult populations: a systematic review and meta-analysis of cohort studies. PLoS One 2016; 11: e0157461. doi: 10.1371/journal.pone.0157461 [DOI] [PMC free article] [PubMed] [Google Scholar]
89.Vanderhout SM, Aglipay M, Torabi N, et al. Whole milk compared with reduced-fat milk and childhood overweight: a systematic review and meta-analysis. Am J Clin Nutr 2020; 111: 266–79. doi: 10.1093/ajcn/nqz276 [DOI] [PMC free article] [PubMed] [Google Scholar]
90.Wang W, Wu Y, Zhang D. Association of dairy products consumption with risk of obesity in children and adults: a meta-analysis of mainly cross-sectional studies. Ann Epidemiol 2016; 26: 870–82.e872. doi: 10.1016/j.annepidem.2016.09.005 [DOI] [PubMed] [Google Scholar]
91.Hong JY, Lee JS, Woo HW, et al. Meta-analysis of randomized controlled trials on calcium supplements and dairy products for changes in body weight and obesity indices. Int J Food Sci Nutr 2021; 72: 615–31. doi: 10.1080/09637486.2020.1856794 [DOI] [PubMed] [Google Scholar]
92.Dietary Guidelines Advisory Committee . Scientific Report of the 2020 Dietary Guidelines Advisory Committee: advisory report to the Secretary of Agriculture and the Secretary of Health and Human Services. Washington, DC: U.S. Department of Agriculture, Agricultural Research Service; 2020. [Google Scholar]
93.Bian S, Hu J, Zhang K, et al. Dairy product consumption and risk of hip fracture: a systematic review and meta-analysis. BMC Public Health 2018; 18: 165. doi: 10.1186/s12889-018-5041-5 [DOI] [PMC free article] [PubMed] [Google Scholar]
94.Bischoff-Ferrari HA, Dawson-Hughes B, Baron JA, et al. Milk intake and risk of hip fracture in men and women: a meta-analysis of prospective cohort studies. J Bone Miner Res 2011; 26: 833–9. doi: 10.1002/jbmr.279 [DOI] [PubMed] [Google Scholar]
95.Hidayat K, Du X, Shi BM, et al. Systematic review and meta-analysis of the association between dairy consumption and the risk of hip fracture: critical interpretation of the currently available evidence. Osteoporos Int 2020; 31: 1411–25. doi: 10.1007/s00198-020-05383-3 [DOI] [PubMed] [Google Scholar]
96.Malmir H, Larijani B, Esmaillzadeh A. Consumption of milk and dairy products and risk of osteoporosis and hip fracture: a systematic review and Meta-analysis. Crit Rev Food Sci Nutr 2020; 60: 1722–37. doi: 10.1080/10408398.2019.1590800 [DOI] [PubMed] [Google Scholar]
97.Matía-Martín P, Torrego-Ellacuría M, Larrad-Sainz A, et al. Effects of milk and dairy products on the prevention of osteoporosis and osteoporotic fractures in Europeans and non-Hispanic Whites from North America: a systematic review and updated meta-analysis. Adv Nutr 2019; 10: S120–43. doi: 10.1093/advances/nmy097 [DOI] [PMC free article] [PubMed] [Google Scholar]
98.Ong AM, Kang K, Weiler HA, et al. Fermented milk products and bone health in postmenopausal women: a systematic review of randomized controlled trials, prospective cohorts, and case-control studies. Adv Nutr 2020; 11: 251–65. doi: 10.1093/advances/nmz108 [DOI] [PMC free article] [PubMed] [Google Scholar]
99.Shi Y, Zhan Y, Chen Y, et al. Effects of dairy products on bone mineral density in healthy postmenopausal women: a systematic review and meta-analysis of randomized controlled trials. Arch Osteoporos 2020; 15: 48. doi: 10.1007/s11657-020-0694-y [DOI] [PubMed] [Google Scholar]
100.Dong JY, Szeto IM, Makinen K, et al. Effect of probiotic fermented milk on blood pressure: a meta-analysis of randomised controlled trials. Br J Nutr 2013; 110: 1188–94. doi: 10.1017/S0007114513001712 [DOI] [PubMed] [Google Scholar]
101.Hidayat K, Du HZ, Yang J, et al. Effects of milk proteins on blood pressure: a meta-analysis of randomized control trials. Hypertens Res 2017; 40: 264–70. doi: 10.1038/hr.2016.135 [DOI] [PubMed] [Google Scholar]
102.Ralston RA, Lee JH, Truby H, et al. A systematic review and meta-analysis of elevated blood pressure and consumption of dairy foods. J Hum Hypertens 2012; 26: 3–13. doi: 10.1038/jhh.2011.3 [DOI] [PubMed] [Google Scholar]
103.Soedamah-Muthu SS, Verberne LD, Ding EL, et al. Dairy consumption and incidence of hypertension: a dose-response meta-analysis of prospective cohort studies. Hypertension 2012; 60: 1131–7. doi: 10.1161/HYPERTENSIONAHA.112.195206 [DOI] [PubMed] [Google Scholar]
104.Usinger L, Reimer C, Ibsen H. Fermented milk for hypertension. Cochrane Database Syst Rev 2012; 4: CD008118. doi: 10.1002/14651858.CD008118.pub2 [DOI] [PMC free article] [PubMed] [Google Scholar]
105.Cavero-Redondo I, Alvarez-Bueno C, Sotos-Prieto M, et al. Milk and dairy product consumption and risk of mortality: an overview of systematic reviews and meta-analyses. Adv Nutr 2019; 10: S97–104. doi: 10.1093/advances/nmy128 [DOI] [PMC free article] [PubMed] [Google Scholar]
106.Gao X, Jia HY, Chen GC, et al. Yogurt intake reduces all-cause and cardiovascular disease mortality: a meta-analysis of eight prospective cohort studies. Chin J Integr Med 2020; 26: 462–8. doi: 10.1007/s11655-020-3085-8 [DOI] [PubMed] [Google Scholar]
107.Larsson SC, Crippa A, Orsini N, et al. Milk consumption and mortality from all causes, cardiovascular disease, and cancer: a systematic review and meta-analysis. Nutrients 2015; 7: 7749–63. doi: 10.3390/nu7095363 [DOI] [PMC free article] [PubMed] [Google Scholar]
108.Mazidi M, Mikhailidis DP, Sattar N, et al. Consumption of dairy product and its association with total and cause specific mortality – a population-based cohort study and meta-analysis. Clin Nutr (Edinburgh, Scotland) 2019; 38: 2833–45. doi: 10.1016/j.clnu.2018.12.015 [DOI] [PubMed] [Google Scholar]
109.Mullie P, Pizot C, Autier P. Daily milk consumption and all-cause mortality, coronary heart disease and stroke: a systematic review and meta-analysis of observational cohort studies. BMC Public Health 2016; 16: 1236. doi: 10.1186/s12889-016-3889-9 [DOI] [PMC free article] [PubMed] [Google Scholar]
110.O’Sullivan TA, Hafekost K, Mitrou F, et al. Food sources of saturated fat and the association with mortality: a meta-analysis. Am J Public Health 2013; 103: e31–42. doi: 10.2105/AJPH.2013.301492 [DOI] [PMC free article] [PubMed] [Google Scholar]
111.Pimpin L, Wu JH, Haskelberg H, et al. Is butter back? A systematic review and meta-analysis of butter consumption and risk of cardiovascular disease, diabetes, and total mortality. PLoS One 2016; 11: e0158118. doi: 10.1371/journal.pone.0158118 [DOI] [PMC free article] [PubMed] [Google Scholar]
112.Tong X, Chen GC, Zhang Z, et al. Cheese consumption and risk of all-cause mortality: a meta-analysis of prospective studies. Nutrients 2017; 9(1): 63. doi: 10.3390/nu9010063 [DOI] [PMC free article] [PubMed] [Google Scholar]
113.Giosuè A, Calabrese I, Vitale M, et al. Consumption of dairy foods and cardiovascular disease: a systematic review. Nutrients 2022; 14(4): 831. doi: 10.3390/nu14040831 [DOI] [PMC free article] [PubMed] [Google Scholar]
114.Ulven SM, Holven KB, Gil A, et al. Milk and dairy product consumption and inflammatory biomarkers: an updated systematic review of randomized clinical trials. Adv Nutr 2019; 10: S239–50. doi: 10.1093/advances/nmy072 [DOI] [PMC free article] [PubMed] [Google Scholar]
115.Hirahatake KM, Bruno RS, Bolling BW, et al. Dairy foods and dairy fats: new perspectives on pathways implicated in cardiometabolic health. Adv Nutr 2020; 11: 266–79. doi: 10.1093/advances/nmz105 [DOI] [PMC free article] [PubMed] [Google Scholar]
116.Chen M, Pan A, Malik VS, et al. Effects of dairy intake on body weight and fat: a meta-analysis of randomized controlled trials. Am J Clin Nutr 2012; 96: 735–47. doi: 10.3945/ajcn.112.037119 [DOI] [PMC free article] [PubMed] [Google Scholar]
117.Sundar R, Bhagavandas Rai A, Naveen Kumar J, et al. The role of vitamin D as an adjunct for bone regeneration: a systematic review of literature. Saudi Dent J 2023; 35: 220–32. doi: 10.1016/j.sdentj.2023.02.002 [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0001] 1.Totland TH, Melnæs BK, Lundberg-Hallén N, Helland-Kigen KM, Lund-Blix NA, Myhre JB, et al. Norkost 3. En landsomfattende kostholdsundersøkelse blant menn og kvinner i Norge i alderen 18–70 år, 2010–11. no. 3. Oslo: Helsedirektoratet; 2012. [Google Scholar]

[CIT0002] 2.Itkonen ST, Andersen R, Björk AK, et al. Vitamin D status and current policies to achieve adequate vitamin D intake in the Nordic countries. Scand J Public Health 2021; 49: 616–27. doi: 10.1177/1403494819896878 [DOI] [PubMed] [Google Scholar]

[CIT0003] 3.Borén J, Chapman MJ, Krauss RM, et al. Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel. Eur Heart J 2020; 41: 2313–30. doi: 10.1093/eurheartj/ehz962 [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0004] 4.Ference BA, Ginsberg HN, Graham I, et al. Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel. Eur Heart J 2017; 38: 2459–72. doi: 10.1093/eurheartj/ehx144 [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0005] 5.Jakobsen MU, O’Reilly EJ, Heitmann BL, et al. Major types of dietary fat and risk of coronary heart disease: a pooled analysis of 11 cohort studies. Am J Clin Nutr 2009; 89: 1425–32. doi: 10.3945/ajcn.2008.27124 [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0006] 6.Mozaffarian D, Micha R, Wallace S. Effects on coronary heart disease of increasing polyunsaturated fat in place of saturated fat: a systematic review and meta-analysis of randomized controlled trials. PLoS Med 2010; 7: e1000252. doi: 10.1371/journal.pmed.1000252 [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0007] 7.Sacks FM, Lichtenstein AH, Wu JHY, et al. Dietary fats and cardiovascular disease: a presidential advisory from the American Heart Association. Circulation 2017; 136: e1–e23. 10.1161/CIR.0000000000000510 [DOI] [PubMed] [Google Scholar]

[CIT0008] 8.Hooper L, Martin N, Jimoh OF, et al. Reduction in saturated fat intake for cardiovascular disease. Cochrane Database Syst Rev 2020; 5: CD011737. doi: 10.1002/14651858.CD011737.pub2 [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0009] 9.Mensink RP, Temme EH, Hornstra G. Dietary saturated and trans fatty acids and lipoprotein metabolism. Ann Med 1994; 26: 461–4. doi: 10.3109/07853899409148369 [DOI] [PubMed] [Google Scholar]

[CIT0010] 10.Åkesson A, Andersen LF, Kristjansdottir AG, et al. Health effects associated with foods characteristic of the Nordic diet: a systematic literature review. Food Nutr Res 2013; 57: 22790. doi: 10.3402/fnr.v57i0.22790 [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0011] 11.Blomhoff R, Andersen R, Arnesen EK, et al. Nordic Nutrition Recommendations 2023. Copenhagen: Nordic Council of Ministers; 2023. [Google Scholar]

[CIT0012] 12.Høyer A, Christensen JJ, Arnesen EK, et al. The Nordic Nutrition Recommendations 2022 – prioritisation of topics for de novo systematic reviews. Food Nutr Res 2021; 65: 7828. doi: 10.29219/fnr.v65.7828 [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0013] 13.World Cancer Research/American Institute for Cancer Research . Continuous Update Project Expert Report 2018. Meat, fish and dairy products and the risk of cancer. 2018. [Google Scholar]

[CIT0014] 14.Mayer-Davis E, Leidy H, Mattes R, et al. Beverage consumption and growth, size, body composition, and risk of overweight and obesity: a systematic review. Alexandria, VA: USDA Nutrition Evidence Systematic Review; 2020. [PubMed] [Google Scholar]

[CIT0015] 15.Christensen JJ, Arnesen EK, Andersen R, et al. The Nordic Nutrition Recommendations 2022 – principles and methodologies. Food Nutr Res 2020; 64: 4402. doi: 10.29219/fnr.v64.4402 [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0016] 16.Vimaleswaran KS, Zhou A, Cavadino A, et al. Evidence for a causal association between milk intake and cardiometabolic disease outcomes using a two-sample Mendelian Randomization analysis in up to 1,904,220 individuals. Int J Obes 2021; 45: 1751–62. doi: 10.1038/s41366-021-00841-2 [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0017] 17.Larsson SC, Mason AM, Kar S, et al. Genetically proxied milk consumption and risk of colorectal, bladder, breast, and prostate cancer: a two-sample Mendelian randomization study. BMC Med 2020; 18: 370. [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0018] 18.Bergholdt HKM, Larsen MK, Varbo A, et al. Lactase persistence, milk intake, hip fracture and bone mineral density: a study of 97 811 Danish individuals and a meta-analysis. J Intern Med 2018; 284: 254–69. doi: 10.1111/joim.12753 [DOI] [PubMed] [Google Scholar]

[CIT0019] 19.Ding M, Huang T, Bergholdt HK, et al. Dairy consumption, systolic blood pressure, and risk of hypertension: Mendelian randomization study. BMJ (Clinical research ed) 2017; 356: j1000. doi: 10.1136/bmj.j1000 [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0020] 20.Huang T, Sun D, Heianza Y, et al. Dairy intake and body composition and cardiometabolic traits among adults: Mendelian randomization analysis of 182041 individuals from 18 studies. Clin Chem 2019; 65: 751–60. doi: 10.1373/clinchem.2018.300335 [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0021] 21.Vissers LET, Sluijs I, van der Schouw YT, et al. Dairy product intake and risk of type 2 diabetes in EPIC-InterAct: a Mendelian randomization study. Diabetes Care 2019; 42: 568–75. doi: 10.2337/dc18-2034 [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0022] 22.Mendelian Randomization of Dairy Consumption Working Group Dairy consumption and body mass index among adults: Mendelian randomization analysis of 184802 individuals from 25 studies. Clin Chem 2018; 64: 183–91. doi: 10.1373/clinchem.2017.280701 [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0023] 23.Yang Q, Lin SL, Au Yeung SL, et al. Genetically predicted milk consumption and bone health, ischemic heart disease and type 2 diabetes: a Mendelian randomization study. Eur J Clin Nutr 2017; 71: 1008–12. doi: 10.1038/ejcn.2017.8 [DOI] [PubMed] [Google Scholar]

[CIT0024] 24.Benatar JR, Sidhu K, Stewart RA. Effects of high and low fat dairy food on cardio-metabolic risk factors: a meta-analysis of randomized studies. PLoS One 2013; 8: e76480. doi: 10.1371/journal.pone.0076480 [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0025] 25.Chen GC, Wang Y, Tong X, et al. Cheese consumption and risk of cardiovascular disease: a meta-analysis of prospective studies. Eur J Nutr 2017; 56: 2565–75. doi: 10.1007/s00394-016-1292-z [DOI] [PubMed] [Google Scholar]

[CIT0026] 26.Diez-Fernández A, Álvarez-Bueno C, Martínez-Vizcaíno V, et al. Total dairy, cheese and milk intake and arterial stiffness: a systematic review and meta-analysis of cross-sectional studies. Nutrients 2019; 11(4): 741. doi: 10.3390/nu11040741 [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0027] 27.Drouin-Chartier JP, Brassard D, Tessier-Grenier M, et al. Systematic review of the association between dairy product consumption and risk of cardiovascular-related clinical outcomes. Adv Nutr 2016; 7: 1026–40. doi: 10.3945/an.115.011403 [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0028] 28.Duarte C, Boccardi V, Amaro Andrade P, et al. Dairy versus other saturated fats source and cardiometabolic risk markers: systematic review of randomized controlled trials. Crit Rev Food Sci Nutr 2021; 61: 450–61. doi: 10.1080/10408398.2020.1736509 [DOI] [PubMed] [Google Scholar]

[CIT0029] 29.Dumas AA, Lapointe A, Dugrenier M, et al. A systematic review of the effect of yogurt consumption on chronic diseases risk markers in adults. Eur J Nutr 2017; 56: 1375–92. doi: 10.1007/s00394-016-1341-7 [DOI] [PubMed] [Google Scholar]

[CIT0030] 30.Hu D, Huang J, Wang Y, et al. Dairy foods and risk of stroke: a meta-analysis of prospective cohort studies. Nutr metabolCardiovasc Dis 2014; 24: 460–9. doi: 10.1016/j.numecd.2013.12.006 [DOI] [PubMed] [Google Scholar]

[CIT0031] 31.Jakobsen MU, Trolle E, Outzen M, et al. Intake of dairy products and associations with major atherosclerotic cardiovascular diseases: a systematic review and meta-analysis of cohort studies. Sci Rep 2021; 11: 1303. doi: 10.1038/s41598-020-79708-x [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0032] 32.Kim Y, Je Y. Dairy consumption and risk of metabolic syndrome: a meta-analysis. Diabet Med 2016; 33: 428–40. doi: 10.1111/dme.12970 [DOI] [PubMed] [Google Scholar]

[CIT0033] 33.Lee M, Lee H, Kim J. Dairy food consumption is associated with a lower risk of the metabolic syndrome and its components: a systematic review and meta-analysis. Br J Nutr 2018; 120: 373–84. doi: 10.1017/S0007114518001460 [DOI] [PubMed] [Google Scholar]

[CIT0034] 34.Mena-Sánchez G, Becerra-Tomás N, Babio N, et al. Dairy product consumption in the prevention of metabolic syndrome: a systematic review and meta-analysis of prospective cohort studies. Adv Nutr 2019; 10: S144–53. doi: 10.1093/advances/nmy083 [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0035] 35.Smith CE, Coltell O, Sorlí JV, et al. Associations of the MCM6-rs3754686 proxy for milk intake in Mediterranean and American populations with cardiovascular biomarkers, disease and mortality: Mendelian randomization. Sci Rep 2016; 6: 33188. doi: 10.1038/srep33188 [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0036] 36.Soedamah-Muthu SS, de Goede J. Dairy consumption and cardiometabolic diseases: systematic review and updated meta-analyses of prospective cohort studies. Curr Nutr Rep 2018; 7: 171–82. doi: 10.1007/s13668-018-0253-y [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0037] 37.Soedamah-Muthu SS, Ding EL, Al-Delaimy WK, et al. Milk and dairy consumption and incidence of cardiovascular diseases and all-cause mortality: dose-response meta-analysis of prospective cohort studies. Am J Clin Nutr 2011; 93: 158–71. doi: 10.3945/ajcn.2010.29866 [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0038] 38.Soto-Méndez MJ, Rangel-Huerta OD, Ruiz-López MD, et al. Role of functional fortified dairy products in cardiometabolic health: a systematic review and meta-analyses of randomized clinical trials. Adv Nutr 2019; 10: S251–71. doi: 10.1093/advances/nmz001 [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0039] 39.Wu L, Sun D. Consumption of Yogurt and the incident risk of cardiovascular disease: a meta-analysis of nine cohort studies. Nutrients 2017; 9(3): 315. doi: 10.3390/nu9030315 [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0040] 40.Zhang K, Chen X, Zhang L, et al. Fermented dairy foods intake and risk of cardiovascular diseases: a meta-analysis of cohort studies. Crit Rev Food Sci Nutr 2020; 60: 1189–94. doi: 10.1080/10408398.2018.1564019 [DOI] [PubMed] [Google Scholar]

[CIT0041] 41.Jin S, Je Y. Dairy consumption and risk of metabolic syndrome: results from Korean population and meta-analysis. Nutrients 2021; 13(5): 1574. doi: 10.3390/nu13051574 [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0042] 42.Trieu K, Bhat S, Dai Z, et al. Biomarkers of dairy fat intake, incident cardiovascular disease, and all-cause mortality: a cohort study, systematic review, and meta-analysis. PLoS Med 2021; 18: e1003763. doi: 10.1371/journal.pmed.1003763 [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0043] 43.Ziaei R, Ghavami A, Khalesi S, et al. The effect of probiotic fermented milk products on blood lipid concentrations: a systematic review and meta-analysis of randomized controlled trials. Nutr Metabol Cardiovasc Dis 2021; 31: 997–1015. doi: 10.1016/j.numecd.2020.12.023 [DOI] [PubMed] [Google Scholar]

[CIT0044] 44.Wu Y, Huang R, Wang M, et al. Dairy foods, calcium, and risk of breast cancer overall and for subtypes defined by estrogen receptor status: a pooled analysis of 21 cohort studies. Am J Clin Nutr 2021; 114: 450–61. doi: 10.1093/ajcn/nqab097 [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0045] 45.Guo J, Astrup A, Lovegrove JA, et al. Milk and dairy consumption and risk of cardiovascular diseases and all-cause mortality: dose-response meta-analysis of prospective cohort studies. Eur J Epidemiol 2017; 32: 269–87. doi: 10.1007/s10654-017-0243-1 [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0046] 46.Aune D, Lau R, Chan DSM, et al. Dairy products and colorectal cancer risk: a systematic review and meta-analysis of cohort studies. Ann Oncol 2012; 23: 37–45. doi: 10.1093/annonc/mdr269 [DOI] [PubMed] [Google Scholar]

[CIT0047] 47.Aune D, Navarro Rosenblatt DA, Chan DS, et al. Dairy products, calcium, and prostate cancer risk: a systematic review and meta-analysis of cohort studies. Am J Clin Nutr 2015; 101: 87–117. doi: 10.3945/ajcn.113.067157 [DOI] [PubMed] [Google Scholar]

[CIT0048] 48.Barrubés L, Babio N, Becerra-Tomás N, et al. Association between dairy product consumption and colorectal cancer risk in adults: a systematic review and meta-analysis of epidemiologic studies. Adv Nutr 2018; 10: S190–211. doi: 10.1093/advances/nmy114 [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0049] 49.Bermejo LM, López-Plaza B, Santurino C, et al. Milk and dairy product consumption and bladder cancer risk: a systematic review and meta-analysis of observational studies. Adv Nutr 2019; 10: S224–38. doi: 10.1093/advances/nmy119 [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0050] 50.Chen L, Li M, Li H. Milk and yogurt intake and breast cancer risk: a meta-analysis. Medicine (Baltimore) 2019; 98: e14900. doi: 10.1097/MD.0000000000014900 [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0051] 51.Dong JY, Zhang L, He K, et al. Dairy consumption and risk of breast cancer: a meta-analysis of prospective cohort studies. Breast Cancer Res Treat 2011; 127: 23–31. doi: 10.1007/s10549-011-1467-5 [DOI] [PubMed] [Google Scholar]

[CIT0052] 52.Genkinger JM, Wang M, Li R, et al. Dairy products and pancreatic cancer risk: a pooled analysis of 14 cohort studies. Ann Oncol 2014; 25: 1106–15. doi: 10.1093/annonc/mdu019 [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0053] 53.Guo Y, Shan Z, Ren H, et al. Dairy consumption and gastric cancer risk: a meta-analysis of epidemiological studies. Nutr Cancer 2015; 67: 555–68. doi: 10.1080/01635581.2015.1019634 [DOI] [PubMed] [Google Scholar]

[CIT0054] 54.Jeyaraman MM, Abou-Setta AM, Grant L, et al. Dairy product consumption and development of cancer: an overview of reviews. BMJ Open 2019; 9: e023625. doi: 10.1136/bmjopen-2018-023625 [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0055] 55.Li BL, Jiang GX, Xue Q, et al. Dairy consumption and risk of esophageal squamous cell carcinoma: a meta-analysis of observational studies. Asia Pac J Clin Oncol 2016; 12: e269–79. doi: 10.1111/ajco.12183 [DOI] [PubMed] [Google Scholar]

[CIT0056] 56.Li F, An SL, Zhou Y, et al. Milk and dairy consumption and risk of bladder cancer: a meta-analysis. Urology 2011; 78: 1298–305. doi: 10.1016/j.urology.2011.09.002 [DOI] [PubMed] [Google Scholar]

[CIT0057] 57.Li X, Zhao J, Li P, et al. Dairy products intake and endometrial cancer risk: a meta-analysis of observational studies. Nutrients 2017; 10(1): 25. doi: 10.3390/nu10010025 [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0058] 58.Lu W, Chen H, Niu Y, et al. Dairy products intake and cancer mortality risk: a meta-analysis of 11 population-based cohort studies. Nutr J 2016; 15: 91. doi: 10.1186/s12937-016-0210-9 [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0059] 59.Mao QQ, Dai Y, Lin YW, et al. Milk consumption and bladder cancer risk: a meta-analysis of published epidemiological studies. Nutr Cancer 2011; 63: 1263–71. doi: 10.1080/01635581.2011.614716 [DOI] [PubMed] [Google Scholar]

[CIT0060] 60.Ralston RA, Truby H, Palermo CE, et al. Colorectal cancer and nonfermented milk, solid cheese, and fermented milk consumption: a systematic review and meta-analysis of prospective studies. Crit Rev Food Sci Nutr 2014; 54: 1167–79. doi: 10.1080/10408398.2011.629353 [DOI] [PubMed] [Google Scholar]

[CIT0061] 61.Sergentanis TN, Ntanasis-Stathopoulos I, Tzanninis IG, et al. Meat, fish, dairy products and risk of hematological malignancies in adults – a systematic review and meta-analysis of prospective studies. Leuk Lymphoma 2019; 60: 1978–90. doi: 10.1080/10428194.2018.1563693 [DOI] [PubMed] [Google Scholar]

[CIT0062] 62.Signal V, Huang S, Sarfati D, et al. Dairy consumption and risk of testicular cancer: a systematic review. Nutr Cancer 2018; 70: 710–36. doi: 10.1080/01635581.2018.1470655 [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0063] 63.Tian SB, Yu JC, Kang WM, et al. Association between dairy intake and gastric cancer: a meta-analysis of observational studies. PLoS One 2014; 9: e101728. doi: 10.1371/journal.pone.0101728 [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0064] 64.Wang J, Li X, Zhang D. Dairy product consumption and risk of non-Hodgkin lymphoma: a meta-analysis. Nutrients 2016; 8: 120. doi: 10.3390/nu8030120 [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0065] 65.Wu J, Yu Y, Huang L, et al. Dairy product consumption and bladder cancer risk: a meta-analysis. Nutr Cancer 2020; 72: 377–85. doi: 10.1080/01635581.2019.1637909 [DOI] [PubMed] [Google Scholar]

[CIT0066] 66.Wu J, Zeng R, Huang J, et al. Dietary protein sources and incidence of breast cancer: a dose-response meta-analysis of prospective studies. Nutrients 2016; 8(11): 730. doi: 10.3390/nu8110730 [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0067] 67.Yang Y, Wang X, Yao Q, et al. Dairy product, calcium intake and lung cancer risk: a systematic review with meta-analysis. Sci Rep 2016; 6: 20624. doi: 10.1038/srep20624 [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0068] 68.Yuan J, Li W, Sun W, et al. Milk and dairy products consumption and the risk of oral or oropharyngeal cancer: a meta-analysis. Biosci Rep 2019; 39: BSR20193526. doi: 10.1042/BSR20193526 [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0069] 69.Zhang K, Dai H, Liang W, et al. Fermented dairy foods intake and risk of cancer. Int J Cancer 2019; 144: 2099–108. doi: 10.1002/ijc.31959 [DOI] [PubMed] [Google Scholar]

[CIT0070] 70.Acham M, Wesselius A, van Osch FHM, et al. Intake of milk and other dairy products and the risk of bladder cancer: a pooled analysis of 13 cohort studies. Eur J Clin Nutr 2020; 74: 28–35. doi: 10.1038/s41430-019-0453-6 [DOI] [PubMed] [Google Scholar]

[CIT0071] 71.Chapelle N, Martel M, Toes-Zoutendijk E, et al. Recent advances in clinical practice: colorectal cancer chemoprevention in the average-risk population. Gut 2020; 69: 2244–55. doi: 10.1136/gutjnl-2020-320990 [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0072] 72.He Y, Tao Q, Zhou F, et al. The relationship between dairy products intake and breast cancer incidence: a meta-analysis of observational studies. BMC Cancer 2021; 21: 1109. doi: 10.1186/s12885-021-08854-w [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0073] 73.Jin S, Kim Y, Je Y. Dairy consumption and risks of colorectal cancer incidence and mortality: a meta-analysis of prospective cohort studies. Cancer Epidemiol Biomarkers Prev 2020; 29: 2309–22. doi: 10.1158/1055-9965.EPI-20-0127 [DOI] [PubMed] [Google Scholar]

[CIT0074] 74.Liao MQ, Gao XP, Yu XX, et al. Effects of dairy products, calcium and vitamin D on ovarian cancer risk: a meta-analysis of twenty-nine epidemiological studies. Br J Nutr 2020; 124: 1001–12. doi: 10.1017/S0007114520001075 [DOI] [PubMed] [Google Scholar]

[CIT0075] 75.Wild CP, Weiderpass E, Stewart BW, eds. World cancer report: cancer research for cancer prevention. Lyon, France: International Agency for Research on Cancer; 2020. [PubMed] [Google Scholar]

[CIT0076] 76.Aune D, Norat T, Romundstad P, et al. Dairy products and the risk of type 2 diabetes: a systematic review and dose-response meta-analysis of cohort studies. Am J Clin Nutr 2013; 98: 1066–83. doi: 10.3945/ajcn.113.059030 [DOI] [PubMed] [Google Scholar]

[CIT0077] 77.Chen M, Sun Q, Giovannucci E, et al. Dairy consumption and risk of type 2 diabetes: 3 cohorts of US adults and an updated meta-analysis. BMC Med 2014; 12: 215. doi: 10.1186/s12916-014-0215-1 [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0078] 78.Gao D, Ning N, Wang C, et al. Dairy products consumption and risk of type 2 diabetes: systematic review and dose-response meta-analysis. PLoS One 2013; 8: e73965. doi: 10.1371/journal.pone.0073965 [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0079] 79.O’Connor S, Turcotte AF, Gagnon C, et al. Increased dairy product intake modifies plasma glucose concentrations and glycated hemoglobin: a systematic review and meta-analysis of randomized controlled trials. Adv Nutr 2019; 10: 262–79. doi: 10.1093/advances/nmy074 [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0080] 80.Sochol KM, Johns TS, Buttar RS, et al. The effects of dairy intake on insulin resistance: a systematic review and meta-analysis of randomized clinical trials. Nutrients 2019; 11: 2237. doi: 10.3390/nu11092237 [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0081] 81.Tong X, Dong JY, Wu ZW, et al. Dairy consumption and risk of type 2 diabetes mellitus: a meta-analysis of cohort studies. Eur J Clin Nutr 2011; 65: 1027–31. doi: 10.1038/ejcn.2011.62 [DOI] [PubMed] [Google Scholar]

[CIT0082] 82.Turner KM, Keogh JB, Clifton PM. Dairy consumption and insulin sensitivity: a systematic review of short- and long-term intervention studies. Nutr MetabolCardiovasc Diseases 2015; 25: 3–8. doi: 10.1016/j.numecd.2014.07.013 [DOI] [PubMed] [Google Scholar]

[CIT0083] 83.Salari A, Ghodrat S, Gheflati A, et al. Effect of kefir beverage consumption on glycemic control: a systematic review and meta-analysis of randomized controlled clinical trials. Complement Ther Clin Pract 2021; 44: 101443. doi: 10.1016/j.ctcp.2021.101443 [DOI] [PubMed] [Google Scholar]

[CIT0084] 84.Eales J, Lenoir-Wijnkoop I, King S, et al. Is consuming yoghurt associated with weight management outcomes? Results from a systematic review. Int J Obes (Lond) 2016; 40: 731–46. doi: 10.1038/ijo.2015.202 [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0085] 85.Hartwig FP, Horta BL, Smith GD, et al. Association of lactase persistence genotype with milk consumption, obesity and blood pressure: a Mendelian randomization study in the 1982 Pelotas (Brazil) Birth Cohort, with a systematic review and meta-analysis. Int J Epidemiol 2016; 45: 1573–87. doi: 10.1093/ije/dyw074 [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0086] 86.Lu L, Xun P, Wan Y, et al. Long-term association between dairy consumption and risk of childhood obesity: a systematic review and meta-analysis of prospective cohort studies. Eur J Clin Nutr 2016; 70: 414–23. doi: 10.1038/ejcn.2015.226 [DOI] [PubMed] [Google Scholar]

[CIT0087] 87.Sayon-Orea C, Martínez-González MA, Ruiz-Canela M, et al. Associations between yogurt consumption and weight gain and risk of obesity and metabolic syndrome: a systematic review. Adv Nutr 2017; 8: 146s–54s. doi: 10.3945/an.115.011536 [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0088] 88.Schwingshackl L, Hoffmann G, Schwedhelm C, et al. Consumption of dairy products in relation to changes in anthropometric variables in adult populations: a systematic review and meta-analysis of cohort studies. PLoS One 2016; 11: e0157461. doi: 10.1371/journal.pone.0157461 [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0089] 89.Vanderhout SM, Aglipay M, Torabi N, et al. Whole milk compared with reduced-fat milk and childhood overweight: a systematic review and meta-analysis. Am J Clin Nutr 2020; 111: 266–79. doi: 10.1093/ajcn/nqz276 [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0090] 90.Wang W, Wu Y, Zhang D. Association of dairy products consumption with risk of obesity in children and adults: a meta-analysis of mainly cross-sectional studies. Ann Epidemiol 2016; 26: 870–82.e872. doi: 10.1016/j.annepidem.2016.09.005 [DOI] [PubMed] [Google Scholar]

[CIT0091] 91.Hong JY, Lee JS, Woo HW, et al. Meta-analysis of randomized controlled trials on calcium supplements and dairy products for changes in body weight and obesity indices. Int J Food Sci Nutr 2021; 72: 615–31. doi: 10.1080/09637486.2020.1856794 [DOI] [PubMed] [Google Scholar]

[CIT0092] 92.Dietary Guidelines Advisory Committee . Scientific Report of the 2020 Dietary Guidelines Advisory Committee: advisory report to the Secretary of Agriculture and the Secretary of Health and Human Services. Washington, DC: U.S. Department of Agriculture, Agricultural Research Service; 2020. [Google Scholar]

[CIT0093] 93.Bian S, Hu J, Zhang K, et al. Dairy product consumption and risk of hip fracture: a systematic review and meta-analysis. BMC Public Health 2018; 18: 165. doi: 10.1186/s12889-018-5041-5 [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0094] 94.Bischoff-Ferrari HA, Dawson-Hughes B, Baron JA, et al. Milk intake and risk of hip fracture in men and women: a meta-analysis of prospective cohort studies. J Bone Miner Res 2011; 26: 833–9. doi: 10.1002/jbmr.279 [DOI] [PubMed] [Google Scholar]

[CIT0095] 95.Hidayat K, Du X, Shi BM, et al. Systematic review and meta-analysis of the association between dairy consumption and the risk of hip fracture: critical interpretation of the currently available evidence. Osteoporos Int 2020; 31: 1411–25. doi: 10.1007/s00198-020-05383-3 [DOI] [PubMed] [Google Scholar]

[CIT0096] 96.Malmir H, Larijani B, Esmaillzadeh A. Consumption of milk and dairy products and risk of osteoporosis and hip fracture: a systematic review and Meta-analysis. Crit Rev Food Sci Nutr 2020; 60: 1722–37. doi: 10.1080/10408398.2019.1590800 [DOI] [PubMed] [Google Scholar]

[CIT0097] 97.Matía-Martín P, Torrego-Ellacuría M, Larrad-Sainz A, et al. Effects of milk and dairy products on the prevention of osteoporosis and osteoporotic fractures in Europeans and non-Hispanic Whites from North America: a systematic review and updated meta-analysis. Adv Nutr 2019; 10: S120–43. doi: 10.1093/advances/nmy097 [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0098] 98.Ong AM, Kang K, Weiler HA, et al. Fermented milk products and bone health in postmenopausal women: a systematic review of randomized controlled trials, prospective cohorts, and case-control studies. Adv Nutr 2020; 11: 251–65. doi: 10.1093/advances/nmz108 [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0099] 99.Shi Y, Zhan Y, Chen Y, et al. Effects of dairy products on bone mineral density in healthy postmenopausal women: a systematic review and meta-analysis of randomized controlled trials. Arch Osteoporos 2020; 15: 48. doi: 10.1007/s11657-020-0694-y [DOI] [PubMed] [Google Scholar]

[CIT0100] 100.Dong JY, Szeto IM, Makinen K, et al. Effect of probiotic fermented milk on blood pressure: a meta-analysis of randomised controlled trials. Br J Nutr 2013; 110: 1188–94. doi: 10.1017/S0007114513001712 [DOI] [PubMed] [Google Scholar]

[CIT0101] 101.Hidayat K, Du HZ, Yang J, et al. Effects of milk proteins on blood pressure: a meta-analysis of randomized control trials. Hypertens Res 2017; 40: 264–70. doi: 10.1038/hr.2016.135 [DOI] [PubMed] [Google Scholar]

[CIT0102] 102.Ralston RA, Lee JH, Truby H, et al. A systematic review and meta-analysis of elevated blood pressure and consumption of dairy foods. J Hum Hypertens 2012; 26: 3–13. doi: 10.1038/jhh.2011.3 [DOI] [PubMed] [Google Scholar]

[CIT0103] 103.Soedamah-Muthu SS, Verberne LD, Ding EL, et al. Dairy consumption and incidence of hypertension: a dose-response meta-analysis of prospective cohort studies. Hypertension 2012; 60: 1131–7. doi: 10.1161/HYPERTENSIONAHA.112.195206 [DOI] [PubMed] [Google Scholar]

[CIT0104] 104.Usinger L, Reimer C, Ibsen H. Fermented milk for hypertension. Cochrane Database Syst Rev 2012; 4: CD008118. doi: 10.1002/14651858.CD008118.pub2 [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0105] 105.Cavero-Redondo I, Alvarez-Bueno C, Sotos-Prieto M, et al. Milk and dairy product consumption and risk of mortality: an overview of systematic reviews and meta-analyses. Adv Nutr 2019; 10: S97–104. doi: 10.1093/advances/nmy128 [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0106] 106.Gao X, Jia HY, Chen GC, et al. Yogurt intake reduces all-cause and cardiovascular disease mortality: a meta-analysis of eight prospective cohort studies. Chin J Integr Med 2020; 26: 462–8. doi: 10.1007/s11655-020-3085-8 [DOI] [PubMed] [Google Scholar]

[CIT0107] 107.Larsson SC, Crippa A, Orsini N, et al. Milk consumption and mortality from all causes, cardiovascular disease, and cancer: a systematic review and meta-analysis. Nutrients 2015; 7: 7749–63. doi: 10.3390/nu7095363 [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0108] 108.Mazidi M, Mikhailidis DP, Sattar N, et al. Consumption of dairy product and its association with total and cause specific mortality – a population-based cohort study and meta-analysis. Clin Nutr (Edinburgh, Scotland) 2019; 38: 2833–45. doi: 10.1016/j.clnu.2018.12.015 [DOI] [PubMed] [Google Scholar]

[CIT0109] 109.Mullie P, Pizot C, Autier P. Daily milk consumption and all-cause mortality, coronary heart disease and stroke: a systematic review and meta-analysis of observational cohort studies. BMC Public Health 2016; 16: 1236. doi: 10.1186/s12889-016-3889-9 [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0110] 110.O’Sullivan TA, Hafekost K, Mitrou F, et al. Food sources of saturated fat and the association with mortality: a meta-analysis. Am J Public Health 2013; 103: e31–42. doi: 10.2105/AJPH.2013.301492 [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0111] 111.Pimpin L, Wu JH, Haskelberg H, et al. Is butter back? A systematic review and meta-analysis of butter consumption and risk of cardiovascular disease, diabetes, and total mortality. PLoS One 2016; 11: e0158118. doi: 10.1371/journal.pone.0158118 [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0112] 112.Tong X, Chen GC, Zhang Z, et al. Cheese consumption and risk of all-cause mortality: a meta-analysis of prospective studies. Nutrients 2017; 9(1): 63. doi: 10.3390/nu9010063 [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0113] 113.Giosuè A, Calabrese I, Vitale M, et al. Consumption of dairy foods and cardiovascular disease: a systematic review. Nutrients 2022; 14(4): 831. doi: 10.3390/nu14040831 [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0114] 114.Ulven SM, Holven KB, Gil A, et al. Milk and dairy product consumption and inflammatory biomarkers: an updated systematic review of randomized clinical trials. Adv Nutr 2019; 10: S239–50. doi: 10.1093/advances/nmy072 [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0115] 115.Hirahatake KM, Bruno RS, Bolling BW, et al. Dairy foods and dairy fats: new perspectives on pathways implicated in cardiometabolic health. Adv Nutr 2020; 11: 266–79. doi: 10.1093/advances/nmz105 [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0116] 116.Chen M, Pan A, Malik VS, et al. Effects of dairy intake on body weight and fat: a meta-analysis of randomized controlled trials. Am J Clin Nutr 2012; 96: 735–47. doi: 10.3945/ajcn.112.037119 [DOI] [PMC free article] [PubMed] [Google Scholar]

[CIT0117] 117.Sundar R, Bhagavandas Rai A, Naveen Kumar J, et al. The role of vitamin D as an adjunct for bone regeneration: a systematic review of literature. Saudi Dent J 2023; 35: 220–32. doi: 10.1016/j.sdentj.2023.02.002 [DOI] [PMC free article] [PubMed] [Google Scholar]

PERMALINK

Milk and dairy products – a scoping review for Nordic Nutrition Recommendations 2023

Kirsten Bjørklund Holven

Emily Sonestedt

Abstract

Popular scientific summary

Box 1.

Methods

Diet intake in Nordic and Baltic countries

Table 1.

Health outcomes

Dairy and cardiovascular disease or risk factors

Dairy and cancer

Dairy and risk of type 2 diabetes, overweight, and obesity

Dairy and bone health

Dairy and other health markers

Mendelian randomization studies using genetic variation as a proxy for long-term milk intake

Mechanisms

Cardiovascular disease

Cancer

Diabetes, overweight, and obesity

Bone health

Food-based dietary guidelines

Summary

Data gaps for future research

Conflict of interest and funding

References

ACTIONS

PERMALINK

RESOURCES

Cite

Add to Collections

PERMALINK

Milk and dairy products – a scoping review for Nordic Nutrition Recommendations 2023

Kirsten Bjørklund Holven

Emily Sonestedt

Abstract

Popular scientific summary

Box 1.

Methods

Diet intake in Nordic and Baltic countries

Table 1.

Health outcomes

Dairy and cardiovascular disease or risk factors

Dairy and cancer

Dairy and risk of type 2 diabetes, overweight, and obesity

Dairy and bone health

Dairy and other health markers

Mendelian randomization studies using genetic variation as a proxy for long-term milk intake

Mechanisms

Cardiovascular disease

Cancer

Diabetes, overweight, and obesity

Bone health

Food-based dietary guidelines

Summary

Data gaps for future research

Conflict of interest and funding

References

ACTIONS

PERMALINK

RESOURCES

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