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. 2024 Dec 15;14(12):5752–5768. doi: 10.62347/QCDR9612

Figure 6.

Figure 6

The combination of DX126-262 with Cisplatin and 5-FU did not result in significant overlapping toxicities in NCI-N87 xenograft models. (A-C) Body weight-time curves of BALB/c nude mice under treatment with Control, different doses of DX126-262 or Herceptin (1.5, 3, 6.4 mg/kg) combined with a fixed dose of Cisplatin (1 mg/kg) and 5-FU (15 mg/kg), or DS-8201a (1.5, 3, 6.4 mg/kg) in NCI-N87 xenograft models. Each point represents the mean body weight and SD (n=8). *P<0.05; * indicates significant differences between the group corresponding to the color and the Vehicle group. (D-F) The percentages of body weight changes of BALB/c nude mice under different treatments (1.5 mg/kg dose in D, 3 mg/kg dose in E, 6.4 mg/kg dose in F) were calculated and shown as Mean ± SD. *P<0.05, **P<0.01; * indicates significant differences between the group corresponding to the color and the Vehicle group.