Table 2.

Clinical trials of therapies to promote adult neurogenesis of patients with neurodegenerative diseases

Pro-neurogenic therapeutical intervention	Condition or disease	Clinical trial Identifier	Clinical trial Phase	Start date	Completion date	Status	Results	Ref.
Exercise and tDCS	Major and mild neurocognitive disorder due to AD or mixed AD/vascular disease	NCT03670615	N/A	2018	2025	Recruiting	Not posted	NA
Dietary restriction and/or extended periods of mastication	Aging and cognitive decline	NCT03457870	N/A	2018	2020	Completed	↑ Recognition memory, and pattern separation	[352, 353]
Intravenous administration of sovateltide	AD, dementia	NCT04052737	II	2019	2023	Completed	Not posted	NA
Intravenous administration of allopregnanolone	AD, late onset AD	NCT04838301	II	2023	2025	Not yet recruiting	Not posted	NA

Abbreviations: AD, Alzheimer’s disease; AAV2, adeno-associated virus type 2; N/A, Not Applicable; tDCS, transcranial direct current stimulation