Table 2.
Cause-Specific Hazards Regression Models for Cancer Death, Non–Breast Cancer Malignancy, and New Chemotherapy
| Exposure | Cancer Death |
Non–Breast Cancer Malignancy |
New Chemotherapy |
||||||
|---|---|---|---|---|---|---|---|---|---|
| HR (95% CI) | P Value | E Value | HR (95% CI) | P Value | E Value | HR (95% CI) | P Value | E Value | |
| Incident MI/HF | 3.94 (3.38-4.59) | <0.001 | 7.34 | 1.39 (1.06-1.82) | 0.016 | 2.13 | 1.25 (1.02-1.53) | 0.029 | 1.61 |
| Incident MI | 2.14 (1.32-3.45) | 0.002 | 3.7 | 1.42 (0.91-2.21) | 0.12 | — | 0.99 (0.74-1.31) | 0.93 | |
| Incident HF | 4.50 (3.84-5.29) | <0.001 | 8.47 | 1.60 (1.32-1.92) | <0.001 | 2.58 | 1.21 (1.08-1.37) | 0.002 | 1.54 |
| Incident MI and HF | 1.79 (0.80-4.00) | 0.15 | — | 0.70 (0.31-1.56) | 0.38 | — | 0.94 (0.60-1.47) | 0.77 | |
Covariates in all models include age, neighborhood income quintile, rural residence, Charlson Comorbidity Index, chemotherapy, radiotherapy, trastuzumab, left-sided breast cancer, diabetes, hypertension, breast cancer stage at diagnosis, year of cohort entry, chronic obstructive pulmonary disease, and chronic kidney disease.
Abbreviations as in Table 1.