Abstract
The egg contains a set of molecules that can be used to trigger cell-shape changes leading to morphogenetic movements. The temporally and spatially controlled activation of these molecules, and hence the choreography of gastrulation movements, is determined by region-specific expression of transcription factors which turn on a set of downstream targets whose products mediate the successive steps of gastrulation.
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Selected References
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- Barrett K., Leptin M., Settleman J. The Rho GTPase and a putative RhoGEF mediate a signaling pathway for the cell shape changes in Drosophila gastrulation. Cell. 1997 Dec 26;91(7):905–915. doi: 10.1016/s0092-8674(00)80482-1. [DOI] [PubMed] [Google Scholar]
- Beiman M., Shilo B. Z., Volk T. Heartless, a Drosophila FGF receptor homolog, is essential for cell migration and establishment of several mesodermal lineages. Genes Dev. 1996 Dec 1;10(23):2993–3002. doi: 10.1101/gad.10.23.2993. [DOI] [PubMed] [Google Scholar]
- Brönner G., Chu-LaGraff Q., Doe C. Q., Cohen B., Weigel D., Taubert H., Jäckle H. Sp1/egr-like zinc-finger protein required for endoderm specification and germ-layer formation in Drosophila. Nature. 1994 Jun 23;369(6482):664–668. doi: 10.1038/369664a0. [DOI] [PubMed] [Google Scholar]
- Costa M., Wilson E. T., Wieschaus E. A putative cell signal encoded by the folded gastrulation gene coordinates cell shape changes during Drosophila gastrulation. Cell. 1994 Mar 25;76(6):1075–1089. doi: 10.1016/0092-8674(94)90384-0. [DOI] [PubMed] [Google Scholar]
- Edgar B. A., O'Farrell P. H. Genetic control of cell division patterns in the Drosophila embryo. Cell. 1989 Apr 7;57(1):177–187. doi: 10.1016/0092-8674(89)90183-9. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gisselbrecht S., Skeath J. B., Doe C. Q., Michelson A. M. heartless encodes a fibroblast growth factor receptor (DFR1/DFGF-R2) involved in the directional migration of early mesodermal cells in the Drosophila embryo. Genes Dev. 1996 Dec 1;10(23):3003–3017. doi: 10.1101/gad.10.23.3003. [DOI] [PubMed] [Google Scholar]
- Hart M. J., Jiang X., Kozasa T., Roscoe W., Singer W. D., Gilman A. G., Sternweis P. C., Bollag G. Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13. Science. 1998 Jun 26;280(5372):2112–2114. doi: 10.1126/science.280.5372.2112. [DOI] [PubMed] [Google Scholar]
- Häcker U., Perrimon N. DRhoGEF2 encodes a member of the Dbl family of oncogenes and controls cell shape changes during gastrulation in Drosophila. Genes Dev. 1998 Jan 15;12(2):274–284. doi: 10.1101/gad.12.2.274. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ip Y. T., Maggert K., Levine M. Uncoupling gastrulation and mesoderm differentiation in the Drosophila embryo. EMBO J. 1994 Dec 15;13(24):5826–5834. doi: 10.1002/j.1460-2075.1994.tb06926.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kosman D., Ip Y. T., Levine M., Arora K. Establishment of the mesoderm-neuroectoderm boundary in the Drosophila embryo. Science. 1991 Oct 4;254(5028):118–122. doi: 10.1126/science.1925551. [DOI] [PubMed] [Google Scholar]
- Kozasa T., Jiang X., Hart M. J., Sternweis P. M., Singer W. D., Gilman A. G., Bollag G., Sternweis P. C. p115 RhoGEF, a GTPase activating protein for Galpha12 and Galpha13. Science. 1998 Jun 26;280(5372):2109–2111. doi: 10.1126/science.280.5372.2109. [DOI] [PubMed] [Google Scholar]
- Leptin M., Grunewald B. Cell shape changes during gastrulation in Drosophila. Development. 1990 Sep;110(1):73–84. doi: 10.1242/dev.110.1.73. [DOI] [PubMed] [Google Scholar]
- Leptin M. twist and snail as positive and negative regulators during Drosophila mesoderm development. Genes Dev. 1991 Sep;5(9):1568–1576. doi: 10.1101/gad.5.9.1568. [DOI] [PubMed] [Google Scholar]
- Merrill P. T., Sweeton D., Wieschaus E. Requirements for autosomal gene activity during precellular stages of Drosophila melanogaster. Development. 1988 Nov;104(3):495–509. doi: 10.1242/dev.104.3.495. [DOI] [PubMed] [Google Scholar]
- Michelson A. M., Gisselbrecht S., Buff E., Skeath J. B. Heartbroken is a specific downstream mediator of FGF receptor signalling in Drosophila. Development. 1998 Nov;125(22):4379–4389. doi: 10.1242/dev.125.22.4379. [DOI] [PubMed] [Google Scholar]
- Miller K. G., Field C. M., Alberts B. M. Actin-binding proteins from Drosophila embryos: a complex network of interacting proteins detected by F-actin affinity chromatography. J Cell Biol. 1989 Dec;109(6 Pt 1):2963–2975. doi: 10.1083/jcb.109.6.2963. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Morize P., Christiansen A. E., Costa M., Parks S., Wieschaus E. Hyperactivation of the folded gastrulation pathway induces specific cell shape changes. Development. 1998 Feb;125(4):589–597. doi: 10.1242/dev.125.4.589. [DOI] [PubMed] [Google Scholar]
- Oda H., Tsukita S., Takeichi M. Dynamic behavior of the cadherin-based cell-cell adhesion system during Drosophila gastrulation. Dev Biol. 1998 Nov 15;203(2):435–450. doi: 10.1006/dbio.1998.9047. [DOI] [PubMed] [Google Scholar]
- Oda H., Uemura T., Harada Y., Iwai Y., Takeichi M. A Drosophila homolog of cadherin associated with armadillo and essential for embryonic cell-cell adhesion. Dev Biol. 1994 Oct;165(2):716–726. doi: 10.1006/dbio.1994.1287. [DOI] [PubMed] [Google Scholar]
- Parks S., Wieschaus E. The Drosophila gastrulation gene concertina encodes a G alpha-like protein. Cell. 1991 Jan 25;64(2):447–458. doi: 10.1016/0092-8674(91)90652-f. [DOI] [PubMed] [Google Scholar]
- Perrimon N., Lanjuin A., Arnold C., Noll E. Zygotic lethal mutations with maternal effect phenotypes in Drosophila melanogaster. II. Loci on the second and third chromosomes identified by P-element-induced mutations. Genetics. 1996 Dec;144(4):1681–1692. doi: 10.1093/genetics/144.4.1681. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pignoni F., Baldarelli R. M., Steingrímsson E., Diaz R. J., Patapoutian A., Merriam J. R., Lengyel J. A. The Drosophila gene tailless is expressed at the embryonic termini and is a member of the steroid receptor superfamily. Cell. 1990 Jul 13;62(1):151–163. doi: 10.1016/0092-8674(90)90249-e. [DOI] [PubMed] [Google Scholar]
- Reuter R., Grunewald B., Leptin M. A role for the mesoderm in endodermal migration and morphogenesis in Drosophila. Development. 1993 Dec;119(4):1135–1145. doi: 10.1242/dev.119.4.1135. [DOI] [PubMed] [Google Scholar]
- Reuter R., Leptin M. Interacting functions of snail, twist and huckebein during the early development of germ layers in Drosophila. Development. 1994 May;120(5):1137–1150. doi: 10.1242/dev.120.5.1137. [DOI] [PubMed] [Google Scholar]
- Shishido E., Higashijima S., Emori Y., Saigo K. Two FGF-receptor homologues of Drosophila: one is expressed in mesodermal primordium in early embryos. Development. 1993 Feb;117(2):751–761. doi: 10.1242/dev.117.2.751. [DOI] [PubMed] [Google Scholar]
- St Johnston D., Nüsslein-Volhard C. The origin of pattern and polarity in the Drosophila embryo. Cell. 1992 Jan 24;68(2):201–219. doi: 10.1016/0092-8674(92)90466-p. [DOI] [PubMed] [Google Scholar]
- Sweeton D., Parks S., Costa M., Wieschaus E. Gastrulation in Drosophila: the formation of the ventral furrow and posterior midgut invaginations. Development. 1991 Jul;112(3):775–789. doi: 10.1242/dev.112.3.775. [DOI] [PubMed] [Google Scholar]
- Tepass U., Hartenstein V. Epithelium formation in the Drosophila midgut depends on the interaction of endoderm and mesoderm. Development. 1994 Mar;120(3):579–590. doi: 10.1242/dev.120.3.579. [DOI] [PubMed] [Google Scholar]
- Vincent S., Wilson R., Coelho C., Affolter M., Leptin M. The Drosophila protein Dof is specifically required for FGF signaling. Mol Cell. 1998 Oct;2(4):515–525. doi: 10.1016/s1097-2765(00)80151-3. [DOI] [PubMed] [Google Scholar]
- Young P. E., Pesacreta T. C., Kiehart D. P. Dynamic changes in the distribution of cytoplasmic myosin during Drosophila embryogenesis. Development. 1991 Jan;111(1):1–14. doi: 10.1242/dev.111.1.1. [DOI] [PubMed] [Google Scholar]
- Zusman S. B., Wieschaus E. F. Requirements for zygotic gene activity during gastrulation in Drosophila melanogaster. Dev Biol. 1985 Oct;111(2):359–371. doi: 10.1016/0012-1606(85)90490-7. [DOI] [PubMed] [Google Scholar]
