Figure 4.

In vivo antibiofilm activity of MSNs and coassemblies. a) Images of biofilm‐colonized implants in mice treated with drug‐loaded single MSNs, coassemblies, or free drugs. Black arrows indicate implants failing to adhere to host tissue; white arrow indicates successful adhesion. b) Quantification of bacterial cells on biofilm‐colonized implants. c) SEM images of implant inner surfaces, with red arrows highlighting bacterial cells and yellow arrows indicating host cells. d) Histopathological images of tissues at implant sites, with blue arrows indicating damaged host muscle tissues suffering from inflammation. Reproduced (adapted) with permission.^{[ 313 ]} Copyright 2020, American Chemical Society.