Table 2.
Peptide | Sequence | Patent number | Bacteria Biofilm specie | Highlight | Assignee |
---|---|---|---|---|---|
DRGN‐1 | PSKKTKPVKPKKVA‐NH2 | WO2018022875 |
P. aeruginosa: 0.01‐10 µg mL−1; S. aureus: 0.01‐10 µg mL−1; Mixed biofilms. |
The invention provides antimicrobial peptides for wound healing, including the discovery of DRGN‐1, a synthetic peptide derived from Komodo dragon. DRGN‐1 shows promise in treating infected wounds, including those with mixed biofilms, without harming human cells. This suggests DRGN‐1 as a potential antibiotic alternative, particularly beneficial for chronic diabetic wounds and combat injuries. | George Mason Research Foundation, Inc., United States |
ATRA1A | KRAKKFFKKLK‐NH2 | ||||
COG1410 | Ac‐AS‐Aib‐LRKL‐Aib‐KRLL‐NH2 and analogs | WO2024015914 | P. gingivalis: 16–64 µg mL−1. | The study provides an amount of peptide compounds with antimicrobial activity, especially, against P. gingivalis. Also, the peptide COG1410 showed a synergism when associated with polymyxin B against A. baumannii | Regennova, Inc., United States |
MH5C | ILGPVLGLVSDTLDDVLGIL‐COOH | WO2021154703 |
P. aeruginosa: 90 µM E. coli: 90 µM |
The study provides a peptide conjugate comprising a polyethylene Gcol (PEG) polymer conjugated to two different antimicrobial peptides for treatment or prevention of biofilms. | University of Puerto Rico, Puerto Rico |
MH5C‐Cys | ILGPVLGLVSDTLDDVLGILC‐COOH | ||||
C0HJX7 | ATCDLLSGTGANHSACAAHCLLRGNRGGYCNGKAVCVCRN‐NH2 and analogs | WO2018226119 | S. aureus, E. coli, P. aeruginosa, K. pneumoniae, A. baumannii | The invention provides especially a complex of antimicrobial peptides of Calliphora vicina onto the anti‐biofilm activity of antimicrobials and antiseptics. | World Intellectual Property Organization. |
The literature collected was performed on April 8th, 2024, on SciFinder. Aib, amino isobutyric acid