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. 2024 Nov 12;12(1):2410893. doi: 10.1002/advs.202410893

Table 2.

AMP‐Based against biofilm formation—Patent published.

Peptide Sequence Patent number Bacteria Biofilm specie Highlight Assignee
DRGN‐1 PSKKTKPVKPKKVA‐NH2 WO2018022875

P. aeruginosa: 0.01‐10 µg mL−1;

S. aureus: 0.01‐10 µg mL−1;

Mixed biofilms.

The invention provides antimicrobial peptides for wound healing, including the discovery of DRGN‐1, a synthetic peptide derived from Komodo dragon. DRGN‐1 shows promise in treating infected wounds, including those with mixed biofilms, without harming human cells. This suggests DRGN‐1 as a potential antibiotic alternative, particularly beneficial for chronic diabetic wounds and combat injuries. George Mason Research Foundation, Inc., United States
ATRA1A KRAKKFFKKLK‐NH2
COG1410 Ac‐AS‐Aib‐LRKL‐Aib‐KRLL‐NH2 and analogs WO2024015914 P. gingivalis: 16–64 µg mL−1. The study provides an amount of peptide compounds with antimicrobial activity, especially, against P. gingivalis. Also, the peptide COG1410 showed a synergism when associated with polymyxin B against A. baumannii Regennova, Inc., United States
MH5C ILGPVLGLVSDTLDDVLGIL‐COOH WO2021154703

P. aeruginosa: 90 µM

E. coli: 90 µM

The study provides a peptide conjugate comprising a polyethylene Gcol (PEG) polymer conjugated to two different antimicrobial peptides for treatment or prevention of biofilms. University of Puerto Rico, Puerto Rico
MH5C‐Cys ILGPVLGLVSDTLDDVLGILC‐COOH
C0HJX7 ATCDLLSGTGANHSACAAHCLLRGNRGGYCNGKAVCVCRN‐NH2 and analogs WO2018226119 S. aureus, E. coli, P. aeruginosa, K. pneumoniae, A. baumannii The invention provides especially a complex of antimicrobial peptides of Calliphora vicina onto the anti‐biofilm activity of antimicrobials and antiseptics. World Intellectual Property Organization.

The literature collected was performed on April 8th, 2024, on SciFinder. Aib, amino isobutyric acid