Figure 2.

Variants in metachronous thyroid lymphomas or composite lymphomas. The number of shared and distinct clonal variants in paired lesions and their predicted evolutionary trajectory in each case are indicated. The total number of all clonal variants (including pathogenic, benign, synonymous variants, and those in UTR regions) is given, but only representative pathogenic mutations are shown in detail. CLP, predicted clonally related lymphoma precursor cells; DLBCL, diffuse large B‐cell lymphoma; EMZL, extranodal marginal zone lymphoma of mucosa‐associated lymphoid tissue; FL, follicular lymphoma; trans+ve: translocation positive; VAF, variant allele frequency, for variants shared by paired lesions and so thought to occur in the CLP cells; the two VAF values in brackets correspond to the paired lesions in sequence.