Figure 3.

Variants in thyroid lymphomas and their paired HT lesion. The number of shared and distinct clonal mutations in paired lesions and their predicted evolutionary trajectory are indicated. The total number of all clonal variants (including pathogenic, benign, synonymous variants, and those in UTR regions) is given, but only representative pathogenic mutations are shown in detail. CLP, clonally related lymphoma precursor cells; EMZL, extranodal marginal zone lymphoma of mucosa‐associated lymphoid tissue; FL, follicular lymphoma; HT, Hashimoto's thyroiditis; trans+ve, translocation positive; VAF, variant allele frequency, for variants shared by paired lesions, and so thought to occur in CLP cells; the two VAF values in brackets correspond to the paired lesions in sequence.