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. 2025 Jan 2;18:1–15. doi: 10.2147/JIR.S485007

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© 2025 Wang et al.

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CBD inhibits TGF-β1-induced CCD-18co fibrosis (*means p<0.05 and ** means p<0.01 in the two groups). (A and B) CCK-8 was used to detect cell activity to explore the optimal inducing concentration of TGF-β1 and the therapeutic concentration range of CBD; (C) The morphology of CCD-18Co cells was observed under light microscope; (D) The mRNA levels of α-SMA, Col1agen1 and TIMP-1 in CCD-18co cells were detected by PCR; (E) The protein abundance of α-SMA, Col1agen1 TIMP-2 and MMP3 in CCD-18co cells was detected by WB; (F–I) Image J software was used to quantitatively analyze the protein expression in Figure E; (J–L) IF was used to detect the expressions of α-SMA, Collagen1 and Nrf2 in CCD-18co cells.