Table 4.
Univariate and multivariate analyses of prognostic factors for overall survival
| Factors |
Univariate
|
Multivariate
|
||
|
HR (95%CI)
|
P value
|
HR (95%CI)
|
P value
|
|
| Age (≥ 60 vs < 60), years | 0.86 (0.59-1.24) | 0.410 | ||
| Sex (male vs female) | 1.16 (0.80-1.67) | 0.434 | ||
| Drinking history (no vs yes) | 1.14 (0.78-1.67) | 0.503 | ||
| Smoking history (no vs yes) | 1.12 (0.76-1.64) | 0.567 | ||
| Site (stomach vs gastric and esophageal binding) | 1.10 (0.76-1.60) | 0.613 | ||
| ECOG (0 vs 1) | 1.90 (1.27-2.86) | 0.002a | 1.68 (1.10-2.59) | 0.017a |
| Histological (others vs adenocarcinoma) | 0.86 (0.58-1.28) | 0.466 | ||
| TyG (low vs high) | 0.33 (0.22-0.50) | < 0.001a | 0.36 (0.24-0.55) | < 0.001a |
| CEA (< 3 vs ≥ 3), ng/mL | 1.11 (0.73-1.69) | 0.635 | ||
| AFP (< 15 vs ≥ 15), ng/mL | 1.15 (0.69-1.93) | 0.593 | ||
| CA-199 (< 37 vs ≥ 37), ng/mL | 1.23 (0.85-1.79) | 0.267 | ||
| Liver metastasis (no vs yes) | 1.20 (0.83-1.74) | 0.335 | ||
| Peritoneal metastasis (no vs yes) | 1.27 (0.81-1.98) | 0.294 | ||
| EBV status (infect vs no-infect) | 0.77 (0.45-1.33) | 0.355 | ||
| PD-L1 expression (CPS < 5 vs CPS ≥ 5) | 0.31 (0.19-0.51) | < 0.001a | 0.49 (0.29-0.82) | 0.007a |
| MMR status (pMMR vs dMMR) | 1.21 (0.45-3.30) | 0.707 | ||
| BMI (< 25 vs ≥ 25), kg/m2 | 0.72 (0.45-1.14) | 0.159 | ||
a
P < 0.05.
HR: Hazard ratio; CI: Confidence interval; ECOG: Eastern Cooperative Oncology Group; TyG: Triglyceride glucose; CEA: Carcinoembryonic-antigen; AFP: Alpha-fetoprotein: CA-199: Carbohydrate antigen 199; EBV: Epstein-Barr virus; PD-L1: Programmed cell death ligand 1; CPS: Combined positive score; MMR: Mismatch repair; pMMR: Proficient mismatch repair; dMMR: Deficient mismatch repair; BMI: Body mass index.