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. 2024 Dec 26;17(1):39. doi: 10.3390/cancers17010039

Table 2.

Clinical pathological profiles of studied cases, segregated by mutational status in the two BRCA genes.

Groups Non-Carriers BRCA Carriers Total
Variables Cases 49 9 58
100%
85.5% 15.5%
Age ≤40 years 7 2 χ2 Test “p” value
0.6495
>40 years 39 7
NOS 3 0
Mean 51.6 50.3
Two-sample t-test ”p” value = 0.788
Family history for
breast cancer
Yes 19 5 0.3475
No 30 4
Diagnostic procedure CL 18 1 0.1086
CL + BIO 8 4
OP + HP 23 4
Histogenetic type NOS 16 1 0.187
F-C Ch 5 0
M 28 8
Histopathological
diagnosis
NCO 18 1 0.494
NN 3 0
Malignancies DCIS 28 1 8 0
IDC 19 7
ILC 5 1
Mixed 2 0
MUC 1 0
Molecular
classification
NCO 23 2 0.0034
L-A 12 1
L-B 7 1
HER2+ 5 0
T-N 2 5

Legend: BIO = Biopsy; CL = Clinical diagnosis; DCIS = Ductal Carcinoma In Situ; IDC = Invasive Ductal Carcinoma; F-C Chs = Fibro-cystic changes; HP = Histopathology; ILC = Invasive Lobular Carcinoma; L-A = Luminal A type; L-B = Luminal B type; NCO = Not Carried Out; T-N = Triple-Negative; NCO = Not Carried Out; NN = Non-Neoplastic lesions; NOS = Not Otherwise Specified; M = Malignancies; Mixed = IDC+ ILC; MUC = Mucinous; OP = Surgical procedure.