Table 3.

Gene targets and key cellular processes modulated by miRNAs involved in cancer.

miRNAs	Target Genes	Cellular Processe
miR-34a	UHRF2	Proliferation, regulation of DNA methylation, genomic stability, and response to DNA damage.
	MDM4	Regulates TP53, inhibits cell cycle arrest and apoptosis mediated by p53/TP53 and TP73/p73, and inhibits the degradation of MDM2.
	MET	Growth, survival, cell migration, invasion, cancer progression, and malignancy.
miR-145	SOX 11	Regulates cell proliferation, differentiation, and migration.
	ERG	Proliferation, differentiation, and apoptosis.
	MYO6	Cell migration and invasion.
	GMFB	Proliferation, migration, inflammation, and apoptosis.
	BCR	Cell signaling, proliferation, differentiation, survival, migration, invasion, and apoptosis.
miR-221	FOXS1	Proliferation, migration, invasion, and resistance to apoptosis.
	KIT	Cell survival and proliferation.
	DMTF1	Senescence, apoptosis, cell cycle regulation, and DNA damage response.
	SORCS1	Cell proliferation, migration and invasion, and resistance to apoptosis.
	CCND1	Cell cycle during the G1/S transition, proliferation, evasion of apoptosis, therapy resistance, and invasion.
miR-21	STAT3	Proliferation, invasion, metastasis, angiogenesis, evasion of apoptosis, and therapy resistance.
	SKP2	Cell cycle progression through negative regulation of p27, resistance to apoptosis, invasion, and migration.
	CREBRF	Proliferation, survival, and resistance to apoptosis.
	MALT1	Proliferation, survival, resistance to apoptosis, and inflammatory response.
miR-106a	TP53	Apoptosis, cell cycle regulation, DNA damage response, oxidative stress control, inhibition of invasion and metastasis.
	RB1	Cell cycle, proliferation, senescence, apoptosis, maintenance of genomic stability, invasion, and metastasis.
	E2F1	Cellular proliferation, cell cycle regulation, apoptosis, differentiation, DNA damage response, invasion, and metastasis.
	BCL2L11 (Bim)	Apoptosis, cell cycle, cellular stress response and sensitivity to therapies.