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Formation of dDiz (closed circles), dIz (open triangles) and 8-Cl-dGuo (open squares) by the reaction of dGuo with different concentrations of HOCl. dGuo (1 mM) was incubated with 0–1 mM NaOCl in 100 mM sodium phosphate buffer (pH 7.4) at 37°C for 15 min and subsequently incubated with one molar excess of N-AcCys. The concentration of the products was quantified by RP-HPLC analysis. The data points are expressed as means ± SD (n = 3).
