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Embryonic sost expression and limb deformity in SOSTwt and SOSTvbΔ transgenic mice. (A) High levels of embryonic SOST expression were predominantly detected in the developing limb bud of E10.5 defective mice, as visualized by whole-mount in situ hybridization using a SOST probe that detects human and mouse transcripts. (B) microCT scans of defective SOSTwt and SOSTvbΔ adult limbs overexpressing human SOST.
