Table 3.

Primary and Secondary Outcome Analyses with Different Models for HBV-ACLF Patients

	All (n=589)		Early-stage group (n= 254)		Mid-stage group (n= 167)		End-stage group (n= 168)
	p-value	Result	p-value	Result	p-value	Result	p-value	Result
28-day transplant-free mortality
Log-rank [HR (95% CI)]	<0.001	0.53 (0.38, 0.74)	0.339	0.74 (0.4, 1.37)	0.088	0.52 (0.24, 1.1)	<0.001	0.34 (0.21, 0.55)
Cox model adjusted with all covariates [HR (95% CI)]	0.004	0.54 (0.36, 0.82)	0.267	0.62 (0.27, 1.44)	0.006	0.15 (0.04, 0.58)	<0.001	0.25 (0.12, 0.52)
Cox model adjusted with covariates selected by univariable analyses [HR (95% CI)]	<0.001	0.49 (0.33,0.72)	0.075	0.52 (0.25, 1.07)	0.037	0.35 (0.13, 0.94)	<0.001	0.26 (0.14, 0.49)
Cox model adjusted with covariates selected by selected by random forest algorithm [HR (95% CI)]	<0.001	0.4 (0.28, 0.56)	0.037	0.48 (0.24, 0.96)	0.015	0.36 (0.15, 0.82)	<0.001	0.27 (0.16, 0.45)
Logistic model adjusted with all covariates [OR (95% CI)]	0.014	0.51 (0.29, 0.87)	0.835	0.9 (0.32, 2.53)	0.01	0.04 (0, 0.46)	0.007	0.2 (0.06, 0.64)
Logistic model adjusted with covariates selected by univariable analyses [OR (95% CI)]	0.007	0.5 (0.3, 0.83)	0.487	0.74 (0.31, 1.74)	0.027	0.2 (0.05, 0.83)	0.007	0.26 (0.1, 0.69)
Logistic model adjusted with covariates selected by selected by random forest algorithm [OR (95% CI)]	<0.001	0.41 (0.25, 0.66)	0.18	0.59 (0.27, 1.28)	0.079	0.37 (0.12, 1.12)	<0.001	0.21 (0.09, 0.49)
60-day transplant-free mortality
Log-rank [HR (95% CI)]	0.024	0.71 (0.53, 0.96)	0.96	1.01 (0.58, 1.77)	0.252	0.67 (0.33, 1.33)	<0.001	0.43 (0.28, 0.65)
Cox model adjusted with all covariates [HR (95% CI)]	0.014	0.64 (0.45, 0.91)	0.318	0.69 (0.33, 1.44)	0.002	0.17 (0.05, 0.52)	<0.001	0.21 (0.11, 0.4)
Cox model adjusted with covariates selected by univariable analyses [HR (95% CI)]	0.005	0.61 (0.44, 0.86)	0.124	0.59 (0.31, 1.15)	0.083	0.46 (0.19, 1.11)	<0.001	0.25 (0.14, 0.45)
Cox model adjusted with covariates selected by selected by random forest algorithm [HR (95% CI)]	<0.001	0.53 (0.39, 0.72)	0.124	0.62 (0.34, 1.14)	0.033	0.44 (0.21, 0.94)	<0.001	0.31 (0.2, 0.49)
Logistic model adjusted with all covariates [OR (95% CI)]	0.126	0.66 (0.38, 1.13)	0.963	0.98 (0.35, 2.75)	0.036	0.15 (0.02, 0.89)	0.018	0.22 (0.06, 0.76)
Logistic model adjusted with covariates selected by univariable analyses [OR (95% CI)]	0.069	0.63 (0.38, 1.04)	0.599	0.79 (0.33, 1.88)	0.097	0.34 (0.1, 1.21)	0.024	0.3 (0.1, 0.86)
Logistic model adjusted with covariates selected by selected by random forest algorithm [OR (95% CI)]	0.023	0.58 (0.36, 0.93)	0.627	0.83 (0.39, 1.75)	0.238	0.52 (0.17, 1.55)	0.009	0.31 (0.12, 0.75)
90-day transplant-free mortality
Log-rank [HR (95% CI)]	0.022	0.72 (0.54, 0.95)	0.771	1.08 (0.64, 1.82)	0.442	0.76 (0.39, 1.52)	<0.001	0.39 (0.26, 0.58)
Cox model adjusted with all covariates [HR (95% CI)]	0.01	0.64 (0.45, 0.9)	0.504	0.79 (0.4, 1.57)	0.012	0.26 (0.09, 0.75)	<0.001	0.19 (0.1, 0.36)
Cox model adjusted with covariates selected by univariable analyses [HR (95% CI)]	0.004	0.62 (0.45, 0.86)	0.167	0.65 (0.35, 1.2)	0.193	0.57 (0.24, 1.33)	<0.001	0.24 (0.14, 0.41)
Cox model adjusted with covariates selected by selected by random forest algorithm [HR (95% CI)]	<0.001	0.53 (0.39, 0.72)	0.177	0.68 (0.38, 1.19)	0.107	0.55 (0.26, 1.14)	<0.001	0.28 (0.18, 0.44)
Logistic model adjusted with all covariates [OR (95% CI)]	0.082	0.63 (0.37, 1.06)	0.717	1.21 (0.44, 3.34)	0.13	0.29 (0.06, 1.44)	0.002	0.07 (0.01, 0.38)
Logistic model adjusted with covariates selected by univariable analyses [OR (95% CI)]	0.055	0.61 (0.37, 1.01)	0.934	0.96 (0.42, 2.23)	0.354	0.57 (0.18, 1.86)	0.005	0.18 (0.06, 0.6)
Logistic model adjusted with covariates selected by selected by random forest algorithm [OR (95% CI)]	0.021	0.58 (0.36, 0.92)	0.981	0.99 (0.47, 2.07)	0.501	0.69 (0.24, 2.02)	0.001	0.18 (0.07, 0.5)

Note: Statistical analyses of different models with p-value < 0.05 were displayed in bold.

Abbreviations: OR, Odds Ratio; HR, Hazard Ratio; CI, Confidence Interval.