Table 5.
Effect of imidazo based heterocycle derivative in change in serum biochemistry at dose 300 mg/kg and 1000 mg/kg. Data values are expressed as mean ± S.E.M, n = 3.
| Parameters | Normal range | Units | Control | 1 % DMSO |
IG-01–007 |
IG-01–008 |
IG-01–009 |
|||
|---|---|---|---|---|---|---|---|---|---|---|
| 300 mg/kg | 1000 mg/kg | 300 mg/kg | 1000 mg/kg | 300 mg/kg | 1000 mg/kg | |||||
| SGPT (ALT) | 18–45 | U/L | 48 ± 2.645 | 42 ± 3.214 | 47.66 ± 2.728 | 75.33 ± 4.05 | 60.33 ± 3.756 | 79.0 ± 1.732 | 63 ± 3.785 | 147.33 ± 8.87 |
| SGOT (AST) | 74–183 | U/L | 149 ± 2.081 | 191.66 ± 4.977 | 193 ± 12.74 | 242 ± 3.785 | 255 ± 5.291 | 302.33 ± 4.096 | 283.66 ± 6.33 | 353 ± 7.371 |
| Total protein | 5.2–7.1 | g/dL | 6.30 ± 0.3214 | 6.66 ± 0.296 | 7.03 ± 0.491 | 7.40 ± 0.324 | 7.266 ± 0.523 | 7.60 ± 0.3183 | 7.266 ± 0.491 | 7.866 ± 0.12 |
| Albumin | 3.4–4.8 | g/dL | 4.066 ± 0.5783 | 3.33 ± 0.355 | 3.33 ± 0.437 | 3.683 ± 0.261 | 3.166 ± 0.2905 | 3.67 ± 0.2055 | 2.78 ± 0.3189 | 3.77 ± 0.18950 |
| Globulin | 1.5–2.5 | g/dL | 3.366 ± 0.4255 | 3.866 ± 0.1763 | 3.80 ± 0.404 | 4.006 ± 0.1034 | 4.30 ± 0.529 | 4.35 ± 0.144 | 4.113 ± 0.2623 | 4.286 ± 0.3319 |
| A/G ratio | 1.58–2.67 | - | 2.366 ± 0.348 | 0.92 ± 0.0529 | 0.69 ± 0.0608 | 0.6966 ± 0.0317 | 0.736 ± 0.0523 | 0.923 ± 0.0648 | 0.79 ± 0.032 | 0.8466 ± 0.0317 |
| ALP | 62–230 | U/L | 204 ± 7.81 | 289 ± 8.386 | 307.33 ± 7.218 | 343.0 ± 10.785 | 391.33 ± 9.261 | 501.66 ± 13.64 | 403.33 ± 12.5 | 602.66 ± 8.41 |
| Triglycerides | 20–114 | mg% | 111 ± 3.785 | 114 ± 4.61 | - | 115 ± 4.055 | - | 115.33 ± 5.487 | - | 151.33 ± 5.81 |