Table II.
Recent advances in quantum dots based diagnostics for tuberculosis.
| First author/s, year | Nanomaterials | Detection assays | Target | LOD | Detection time | (Refs.) |
|---|---|---|---|---|---|---|
| Hu et al, 2023 | CdTe:Zn2+ QD-NB | Colorimetric assays | MTB DNA | 2 copies/μl | 55 min | (61) |
| He et al, 2022 | CdTe QD/CoTCPP | Fluorescence quenching | Methyl nicotinate | 0.59 μM | 4 min | (62) |
| Hu et al, 2022 | Double CdTe QDs/nanoCoTPyP | Fluorescence quenching | rpoB531/katG315 | 24/20 pM | 95 min | (63) |
| Kabwe et al, 2022 | MA-CdSe/ZnS QDs | Visual paper-based lateral flow | Anti-MA antibodies | NA | NA | (64) |
| Shi et al, 2024 | CdTe QD/carbon dots | Fluorescence quantification strategy | IFN-γ/IP-10 | 0.3/0.5 ag/ml | 8 h | (65) |
| Kabwe et al, 2022 | MA-GQDs | Lateral flow tests | Anti-MA antibodies | NA | NA | (66) |
| Liang et al, 2021 | CdTe QDs/Cu-TCPP | FRET | IS6110 | 35 pM | 50 min | (67) |
LOD, limit of detection; MTB, Mycobacterium tuberculosis; QD-NB, quantum dot-based nanobeacon; NA, not available; CoTCPP, cobalt-metalized tetrakis(4-carboxyphenyl) porphyrin; nanoCoTPyP, nanocobalt 5,10,15,20-tetra(4-pyridyl)-21H,23H porphine; Mas, mycolic acids; GQDs, graphene quantum dots; FRET, fluorescence resonance energy transfer; TCPP, Tetrakis(4-carboxyphenyl)porphyrin; IP-10, IFN-γ-induced protein 10.