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. 2005 Jun 22;102(27):9607–9612. doi: 10.1073/pnas.0500353102

Fig. 1.

Fig. 1.

Increased cardiac function and reverse remodeling in mice treated with JTV519 3 weeks after MI. (A) Kaplan–Meier survival curve for WT and calstabin-2-/- mice after permanent coronary artery ligation resulting in MI. (B) Quantification of M-mode echocardiograms showing improved ejection fraction (EF) in JTV519-treated WT mice compared with placebo. *, P < 0.05. (C and D) Pressure–volume loop quantifications showing improved cardiac function in JTV519-treated WT compared with calstabin-2-/- mice. dP/dtmax, slope of the maximum derivative of change in systolic pressure over time; Ped, end-systolic pressure; *, P < 0.05.