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. 2005 Jun 22;102(27):9607–9612. doi: 10.1073/pnas.0500353102

Fig. 2.

Fig. 2.

Effect of JTV519 on calstabin-2 affinity to RyR2 in mice with HF. (A) Equivalent amounts of RyR2 were immunoprecipitated with an antibody against RyR2 (top blot). Representative immunoblots (A) and bar graphs (B and C) show the amount of PKA phosphorylation of RyR2 at Ser-2808 (B) and the amount of calstabin-2 (C) bound to RyR2 from WT or calstabin-2-/- mice treated with JTV519 or placebo. Animals were treated with JTV519 by implantable osmotic pumps (0.5 mg·kg-1·h-1 for 28 days after MI).