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. 2005 Jun 22;102(27):9607–9612. doi: 10.1073/pnas.0500353102

Fig. 4.

Fig. 4.

Increased calstabin-1 binding to RyR1 in soleus muscle after treatment with JTV519. (A) Equivalent amounts of RyR2 were immunoprecipitated with an antibody against RyR1 (top blot). Representative immunoblots (A) and bar graphs (B and C) show the amount of PKA phosphorylation of RyR1 at Ser-2844 (B) and the amount of calstabin-1 bound to RyR1 (C) from WT or calstabin-2-/- mice treated with JTV519 or placebo. Mice were treated with JTV519 by implantable osmotic pumps (0.5 mg·kg-1·h-1 for 28 days after MI).